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While no alterationsin in vitro growth kinetics of tumor cells cultured with thiopental could explain these data, significant alterations in cell\u2010mediated immunity were observed. Spleen cells from C57B1\/6 mice treated with thiopental were impaired in their ability to respond in a mixed leukocyte culture (MLC) to BALB\/c stimulator cells. Spleen cells from thiopental\u2010treated mice suppressed the ability of cells from untreated animals to respond in a third\u2010party MLC. The degree of suppression was directly proportional to the number of cells from thiopentaltreated mice in the third party. When these cells were added to an MLC at various times during the culture period, suppression of the early phases of the MLC was seen. Removal of plastic adherent cells from the third party resulted in loss of suppression, but treatment of third\u2010party cells with anti\u2010thy 1.2 serum or irradiation did not prevent suppression. Transfer of spleen cells from thiopental\u2010treated mice enhances growth of the B\u201016 melanoma. Suppressor\u2010cell activity may be one mechanism by which thiopental promotes tumor growth.<\/jats:p>","DOI":"10.1002\/jso.2930220108","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T08:52:35Z","timestamp":1171961555000},"page":"26-32","source":"Crossref","is-referenced-by-count":9,"title":["Suppressor cells and increased primary tumor growth rate induced by thiopental"],"prefix":"10.1002","volume":"22","author":[{"suffix":"III","given":"Edmund 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