{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:33:51Z","timestamp":1760888031028},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":8357,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although gut\u2010associated lymphoid tissue in the form of discrete lymphoid patches (LP\u2010GALT) in mammalian intestine is most prominent in the distal ileum, appendix, and, in some species, the cecal appendage, LP\u2010GALT can be found throughout the intestinal tract. LP\u2010GALT appears as single or multiple subepithelial lymphoid follicles covered by a specialized, structurally unique epithelium. In the colon of the Wistar\/Furth(W\/Fu) rat, LP\u2010GALT appears as aggregates of follicles, or lymphoid patches, that can be detected macroscopically. We studied the relationship between 1,2\u2010dimethylhydrazine\u2010 (DMH) induced colon carcinomas and the lymphoid patch associated epithelium in these animals. In addition, we defined the normal distribution of colonic lymphoid patches in both DMH\u2010treated and control rats. Patches were found macroscopically and confirmed by histologic examination at five constant sites: lower pole of cecum, proximal ascending colon, the major colonic flexure, mid descending colon, and the rectosigmoid. These are also the predominant sites of DMH induced carcinomas in W\/Fu rats. In 120 DMH\u2010treated animals, 109 colon carcinomas were found. Eight percent were in the lower pole of the cecum, 56% in the proximal ascending colon, 16% at the major flexure, 15% in the mid descending colon, and 5% in the rectosigmoid. Lymphoid patches could often be detected histologically in association with DMH\u2010induced tumors. The depth of tumor invasion was found to correlate inversely with our ability to identify tumor\u2010associated lymphoid patches suggesting that tumors arising at the anatomical sites where lymphoid patches occur progressively destroyed them. Of colon tumors confirmed histologically to be associated with lymphoid patches, 88% were superficial lesions confined to the submucosa and 12% were more extensive but confined to the bowel wall. No lymphoid patches could be found associated with tumors that extended through the bowel wall. Thus, DMH\u2010induced colon carcinomas in W\/Fu rats arise at sites containing preexisting LP\u2010GALT with associated specialized epithelium.<\/jats:p>","DOI":"10.1002\/jso.2930240109","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T08:28:53Z","timestamp":1171960133000},"page":"36-40","source":"Crossref","is-referenced-by-count":18,"title":["Gut\u2010associated lymphoid tissue and dimethylhydrazine\u2010induced colorectal carcinoma in the wistar\/furth rat"],"prefix":"10.1002","volume":"24","author":[{"given":"J. M.","family":"Deasy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"G.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Lahey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Madara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-158-40146"},{"key":"e_1_2_1_3_2","first-page":"3293","article-title":"Effects of diet on colon carcinogenesis and the immune system in rats treated with 1,2\u2010dimethylhydrazine","volume":"38","author":"Bansal BR","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90010-5"},{"key":"e_1_2_1_5_2","first-page":"275","article-title":"Colonic lymphoid tissue and its influence on tumor induction in dimethylhydrazine treated rats","volume":"44","author":"Bland PW","year":"1981","journal-title":"Br J Cancer"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00620890"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(76)90040-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.6.1425"},{"key":"e_1_2_1_9_2","first-page":"1","article-title":"Experimental colorectal tumours in the rat","volume":"268","author":"Lindstrom CG","year":"1978","journal-title":"Acta Pathol Microbiol Scand Suppl"},{"key":"e_1_2_1_10_2","unstructured":"MadaraJL HarteP DeasyJ RossD LaheyS SteeleGJr: Evidence for adenoma\u2010adenocarcinoma sequence in dimethylhydrazine induced neoplasms of rat intestinal epithelium.Am J Pathol(in press)."},{"key":"e_1_2_1_11_2","first-page":"1420","article-title":"Confirmation of the two step nature of chemical carcinogenesis in the rat colon adenocarcinoma model","volume":"41","author":"Maskens AP","year":"1981","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0016-5085(77)80254-0","article-title":"Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in normal unobstructed mouse intestine: an ultrastructural study","volume":"72","author":"Owen RL","year":"1977","journal-title":"Gastroenterology"},{"key":"e_1_2_1_13_2","unstructured":"OwenRL JonesAL:Specialized lymphoid follicle epithelial cells in human and non\u2010human primate: A possible antigen uptake site. In \u201cScanning Electron Microscopy\/1974 (Part III).\u201d Proceedings of the Workshop on Advances in Biomedical Applications of SEM. Chicago ITT Research Institute 1974 pp697\u2013704."},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0016-5085(74)80102-2","article-title":"Epithelial cell specialization within human Peyer's patches: An ultrastructural study of intestinal lymphoid patches","volume":"66","author":"Owen RL","year":"1974","journal-title":"Gastroenterology"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01922349"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0300-5089(21)00285-6","article-title":"The gut as lymphoid organ","volume":"5","author":"Parrott DMV","year":"1976","journal-title":"Clin Gastroenterol"},{"key":"e_1_2_1_17_2","first-page":"4156","article-title":"Effect of high fat diet on colon carcinogenesis in F344 rats treated with 1,2\u2010dimethylhydrazine, methylazomethanol acetate or methylnitrosurea","volume":"37","author":"Reddy BS","year":"1977","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(81)90304-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001590205"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910140403"},{"key":"e_1_2_1_21_2","first-page":"164","article-title":"Cell surface antigens in a rat colon model: correlation with inhibition of tumor growth","volume":"82","author":"Steele G","year":"1977","journal-title":"Surgery"},{"key":"e_1_2_1_22_2","first-page":"719","article-title":"Strain differences in susceptibility of rat colon to 1,2\u2010dimethylhydrazine carcinogenesis","volume":"69","author":"Takizana S","year":"1978","journal-title":"Gann"},{"key":"e_1_2_1_23_2","first-page":"505","article-title":"Morphogenesis of chemically induced neoplasms of the large and small intestine in rats","volume":"30","author":"Ward JM","year":"1974","journal-title":"Lab Invest"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930240109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930240109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T07:50:04Z","timestamp":1697788204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930240109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,9]]}},"alternative-id":["10.1002\/jso.2930240109"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930240109","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,9]]}}}