{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T12:46:26Z","timestamp":1725713186741},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":7810,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifty\u2010nine patients with stage D carcinoma of the prostate under different modalities of treatment were studied for creatine phosphokinase isoenzyme BB (CK\u2010BB) and prostatic acid phosphatase (PAP) levels in serum by radioimmunoassay (RIA) technique, in order to study the possible use of CK\u2010BB as a follow\u2010up marker compared to PAP. Thirty\u2010three patients were in stable, 19 in progressive, and seven in regressive clinical state. CK\u2010BB was above normal level in 52 (88%) out of 59 patients with no statistically significant difference between the three clinical states. On the other hand, PAP was above normal level in only 23 patients (38.98%) with statistically significant difference between the three clinical states (P &lt; 0.001).<\/jats:p><jats:p>The PAP\/CK\u2010BB index was below 1 in stable and regressive condition, while it was above 1 in eight out of 19 patients with progressive disease. The PAP\/CK\u2010BB index may be of prognostic importance. CK\u2010BB by RIA was abnormal in more cases than PAP. In this way CK\u2010BB reflects the presence of the tumor and may be used for diagnosis; however, it does not reflect the clinical response as PAP does.<\/jats:p>","DOI":"10.1002\/jso.2930280319","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T09:54:35Z","timestamp":1171965275000},"page":"232-236","source":"Crossref","is-referenced-by-count":1,"title":["Creatine kinase isoenzyme (CK\u2010BB) by RIA as a follow\u2010up marker in stage D cancer of the prostate: Comparison with PAP RIA"],"prefix":"10.1002","volume":"28","author":[{"given":"Ayda","family":"El\u2010Shribiny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Bharvaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald P.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1093\/clinchem\/25.8.1432","article-title":"Creatinc kinase BB: A new tumor\u2010associated marker","volume":"25","author":"Slivermun LM","year":"1979","journal-title":"Clin Chcm"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(75)90441-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365597509134208"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1093\/clinchem\/24.9.1654","article-title":"CK\u2010isoenzymes in serum of patients with cancer of various organs","volume":"24","author":"Hoag GN","year":"1978","journal-title":"Clin Chem"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1093\/clinchem\/22.10.1748","article-title":"Creatinc kinase isoenzyme BB activity in serum of a patient with gastric cancer","volume":"22","author":"Ledcrer WH","year":"1976","journal-title":"Clin Chcm"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197910)44:4<1414::AID-CNCR2820440436>3.0.CO;2-S"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/clinchem\/25.6.1190","article-title":"Serum CK\u2010isoenzyme BB as an indicator of active metastatic disease","volume":"25","author":"Zweig MH","year":"1979","journal-title":"Clin Chcm"},{"key":"e_1_2_1_9_2","first-page":"1174","article-title":"The production of brain type creatine kinase in the serum of patients with oat\u2010cell carcinomas","volume":"22","author":"Coolen RB","year":"1976","journal-title":"Clin Chem"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0610116"},{"key":"e_1_2_1_11_2","first-page":"695","article-title":"An improved procedure for serum creatine phosphokinase determination","volume":"60","author":"Rosalki SB","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(80)90747-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00262406"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(80)90276-4"},{"key":"e_1_2_1_15_2","first-page":"859","article-title":"Assessment by radio\u2010immunoassay serum creatine kinase BB as tumor marker: Studies in patients with various CK\u2010BB concentrations to prostate acid phosphatase concentrations","volume":"66","author":"Zweig MH","year":"1981","journal-title":"JNCI"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930280319","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930280319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T16:15:39Z","timestamp":1697818539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930280319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1002\/jso.2930280319"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930280319","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}