{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:31:14Z","timestamp":1776843074171,"version":"3.51.2"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":7657,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1985,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The lymph node biopsies of 12 patients with lymphadenopathy due to reactive hyperplasia contained lymphocyte populations with increased percentages of B\u2010cells and abnormal numbers of cells with single class surface immunoglobulins. Ten patients were followed for periods of 3\u201330 months: one developed a non\u2010Hodgkin's lymphoma and one Hodgkin's disease. One other has persisting lymph node enlargement. Two patients had nonlymphoid malignancies. The other six remain well without lymphadenopathy. Twenty\u2010five of 40 patients with reactive lymph node hyperplasia and normal kappa\/lambda ratios followed for 9\u201336 months had a similar incidence of lymphoid malignancy and persistent lymph node enlargement. The follow\u2010up data so far available do not support a hypothesis that reactive lymphoid hyperplasia with increased numbers of cells with single class surface immunoglobulin is associated with higher morbidity than reactive hyperplasia containing the usual polytypic lymphocyte populations.<\/jats:p>","DOI":"10.1002\/jso.2930290406","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T10:32:34Z","timestamp":1171967554000},"page":"227-230","source":"Crossref","is-referenced-by-count":11,"title":["Lymphocyte populations with abnormal kappa:lambda ratios in reactive lymphoid hyperplasia"],"prefix":"10.1002","volume":"29","author":[{"given":"Vincent G.","family":"Bain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon O.","family":"Bain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/78.3.316"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/80.3.300"},{"key":"e_1_2_1_4_2","first-page":"64","article-title":"Non\u2010Hodgkin's lymphomas: Analysis of 92 cases using the \u201cinternational\u201d classification","volume":"107","author":"Bain GO","year":"1983","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.4049\/jimmunol.115.4.982","article-title":"Studies of surface immunoglobulins on human B lymphocytes: 1. 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