{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:16Z","timestamp":1762160596920},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":7535,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical, immunopathologic, and virologic features of the lymphoproliferative diseases occurring after renal transplantation have been characterized. Clinically, patients may present with an infectious mononucleosis\u2010like illness or with localized solid tumor masses. These lymphoproliferative diseases have unique histologic features that can be classified as polymorphic diffuse B\u2010cell hyperplasia (PDBH) or polymorphic B\u2010cell lymphoma (PBL). Immunologic cell\u2010typing studies have shown that the majority are polyclonal B\u2010cell proliferations, but monoclonal B\u2010cell tumors have also been documented. These B\u2010cell proliferations may, however, evolve from a benign polyclonal B\u2010cell hyperplasia to a monoclonal malignant lymphoma. The Epstein\u2010Barr virus (EBV) has been implicated as the cause of these disorders. Serologic studies frequently demonstrate evidence of a primary or reactivation infection, touch imprints from involved tissue may stain for the presence of EBNA (Epstein\u2010Barr nuclear antigen), and EBV DNA hybridization studies demonstrate the presence of EBV\u2010specific DNA sequences within tumor cells. Since EBV induces a polyclonal B\u2010cell proliferation in vitro and in vivo, the polyclonality of these diseases also implicates EBV. Acyclovir, a new synthetic antiviral agent that inhibits EBV DNA replication may be effective in some patients during the polyclonal growth phase but is ineffective once the tumor evolves into a monoclonal lymphoma. We have identified several factors that may be useful in predicting responsiveness to acyclovir therapy.<\/jats:p>","DOI":"10.1002\/jso.2930300406","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T10:26:11Z","timestamp":1171967171000},"page":"215-220","source":"Crossref","is-referenced-by-count":21,"title":["Advances in the diagnosis and treatment of EBV\u2010associated lymphoproliferative diseases in immunocompromised hosts"],"prefix":"10.1002","volume":"30","author":[{"given":"Douglas W.","family":"Hanto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Najarian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198505000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198309000-00012"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4760-6_15"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90994-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1182\/blood.V60.1.180.180","article-title":"A monoclonal immunoblastic sarcoma in donor cells bearing Epstein\u2010Barr virus genomes following allogeneic marrow grafting for acute lymphoblastic leukemia. Allogeneic marrow grafting for acute lymphoblastic leukemia","volume":"60","author":"Schubach WH","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198505023121804"},{"key":"e_1_2_1_8_2","first-page":"4243","article-title":"Epstein\u2010Barr virus in a malignant lymphoproliferative disorder of B\u2010cells occurring after thymic epithelial transplantation for combined immunodeficiency","volume":"41","author":"Reece ER","year":"1981","journal-title":"Can Res"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0065-3101(22)00584-9","article-title":"Epstein\u2010Barr virus and the X\u2010linked lymphoproliferative syndrome","volume":"30","author":"Sullivan JL","year":"1984","journal-title":"Adv Pediatr"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6262.425"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198204153061506"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92566-2"},{"key":"e_1_2_1_13_2","first-page":"4262","article-title":"Polymorphic diffuse B\u2010cell hyperplasias and lymphomas in renal transplant recipients","volume":"41","author":"Frizzera G","year":"1981","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198204000-00002"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198402233100801"},{"key":"e_1_2_1_16_2","first-page":"89","article-title":"Acyclovir therapy of Epstein\u2010Barr virus\u2010induced posttransplant lymphoproliferative diseases","volume":"17","author":"Hanto DW","year":"1985","journal-title":"Transpl Proc"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930300406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930300406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T20:30:53Z","timestamp":1697833853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930300406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,12]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,12]]}},"alternative-id":["10.1002\/jso.2930300406"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930300406","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12]]}}}