{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T13:11:05Z","timestamp":1697980265888},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":7384,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The nude (athymic) mouse is currently used to study the effect of gastrin on cancer xenografts. We sought to develop a hypogastrinemic nude mouse model for use in evaluating the effect of hypogastrinemia on such xenografts. Thirty\u2010six non\u2010tumor\u2010bearing nude mice were studied. Eighteen received a nutritionally complete liquid diet; eighteen received standard chow. Six mice from each group were weighed and killed (nonfasting) on days 2, 8, and 15. Mean serum gastrin levels (\u00b1 SEM) for the control group were 118.7 \u00b1 7.5, 118.7 \u00b1 8.7, and 118.0 \u00b1 7.5 pg\/ml on days 2, 8, and 15, respectively. Serum gastrin levels for the liquid diet group significantly decreased to 87.0 \u00b1 7.6, 88.0 \u00b1 9.7, and 66.7 \u00b1 9.6 pg\/ml on the same days. Animals in both groups gained weight normally; there were no significant weight differences between the two groups at any point. No histological abnormalities were seen in stomach, small intestine, colon, cecum, liver, pancreas, spleen or kidney. However, The liquid diet group showed atrophic changes in colon: significant reductions in colon weight and RNA content on days 8 and 15, and significant reduction in colon protein content on day 8. This model of hypogastrinemia is reliable and inexpensive. The nonsurgical nature of the preparation allows excellent survival in this immunodeficient animal.<\/jats:p>","DOI":"10.1002\/jso.2930320114","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T10:58:41Z","timestamp":1171969121000},"page":"50-54","source":"Crossref","is-referenced-by-count":2,"title":["Effect of liquid diet on nude mouse gastrointestinal tract"],"prefix":"10.1002","volume":"32","author":[{"given":"Frank E.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elene M.","family":"Awad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Jellinek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford W.","family":"Deveney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie C.","family":"Laregina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0016-5085(77)80003-6","article-title":"New aspects of the trophic action of gastrointestinal hormones","volume":"72","author":"Johnson LR","year":"1977","journal-title":"Gastroenterology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-132-34353"},{"key":"e_1_2_1_4_2","unstructured":"AwadEM DoerrDE LaReginaMC BashitiHM JellinekM JohnsonFE:Effect of pentagastrin on growth of human gastric adenocarcinoma in nude mice. Proc 13th Int Cong Chemother 1983."},{"key":"e_1_2_1_5_2","first-page":"255","article-title":"Gastrin\u2010enhanced tumor growth of xenotransplantable human gastric carcinoma in nude mice","volume":"10","author":"Ohkura H","year":"1980","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90341-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0016-5085(75)80232-0","article-title":"Structural and hormonal alterations in the gastroin testinal tract of parenterally fed rats","volume":"68","author":"Johnson LR","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0016-5085(75)80233-2","article-title":"Action of gastrin on gastrointestinal structure and function","volume":"68","author":"Johnson LR","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_9_2","first-page":"M1","article-title":"Guide for the care and use of the nude (thymus deficient) mouse in biomedical research","volume":"19","author":"Gullino PM","year":"1976","journal-title":"Inst Lab Anim Resources (ILAR) News"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)70943-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj0620315"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/206093a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/10.10.918"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1973.12096677"},{"key":"e_1_2_1_15_2","first-page":"411","article-title":"Chronic hypergastrinemia produces hypertrophy of the liver and intestine in rats","volume":"27","author":"MacGregor IL","year":"1976","journal-title":"Surg Forum"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(77)90040-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90771-4"},{"key":"e_1_2_1_18_2","first-page":"425","volume-title":"Galveston","author":"Debas HT","year":"1975"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(74)80040-5"},{"key":"e_1_2_1_20_2","unstructured":"JohnsonFE LaReginaMC DoerrDE BashitiHM JellinekM:Trophic effects of exogenous cholecystokinin on hamster and nude mouse pancreas. Proceedings of the joint meeting of American Pancreatic Association and National Pancreatic Cancer Project Chicago 1982."},{"key":"e_1_2_1_21_2","first-page":"1302","article-title":"Effects of chronic administration of CCK on pancreas of the dog and rat","volume":"86","author":"Wood JG","year":"1984","journal-title":"Gastroenterology"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930320114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930320114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:43:53Z","timestamp":1697881433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930320114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1002\/jso.2930320114"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930320114","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}