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The most common presenting symptoms were headache, mental changes, nausea, vomiting, and convulsions. The main neurological findings were hemiparesis, papilledema, visual field defects, and cranial nerve palsies. The most common finding in the cerebrospinal fluid (CSF) was high protein content; CSF cytology was positive in only one case. Computerized tomography was done in 14 cases; all showed a contrast\u2010enhancing lesion. Angiography generally revealed an avascular mass. The most common location above tentorium was the frontal lobe; in four cases the tumor was infratentorial (cerebellum, 3 cases). In five cases there was diffuse involvement of the brain; all had severe dementia and diagnosis was not made until the autopsy. Histologically, the most common type was diffuse histiocytic or immunoblastic lymphoma according to Rappaport and the Working Formulation classification respectively. Radiation therapy alone in five patients gave a median survival of 17 months. Five patients received radiation and chemotherapy, and median survival was 16 months. Two patients developed ocular lymphoma 8 and 36 months later that was treated by radiation.<\/jats:p>","DOI":"10.1002\/jso.2930330208","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T10:48:09Z","timestamp":1171968489000},"page":"95-102","source":"Crossref","is-referenced-by-count":11,"title":["Primary lymphoma of the central nervous system: A clinicopathologic analysis of 26 cases"],"prefix":"10.1002","volume":"33","author":[{"given":"Saeed T.","family":"Vakili","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jans","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homayoon","family":"Shidnia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"935","article-title":"Rappaport classification of non\u2010Hodgkin's lymphoma: Histologic features and clinical significance","volume":"61","author":"Byrne GE","year":"1977","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_4_2","first-page":"95","article-title":"Primary malignant lymphomas of the central nervous system in man","volume":"6","author":"Jellinger K","year":"1975","journal-title":"Acta Neuropathol Suppl"},{"key":"e_1_2_1_5_2","first-page":"69","article-title":"Malignant lymphomas of the nervous system","volume":"6","author":"Zimmerman HM","year":"1975","journal-title":"Acta Neuropathol Suppl"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1929.01140130449031"},{"key":"e_1_2_1_7_2","first-page":"451","article-title":"Perithelioma of brain: Case of multiple primary perithelioma: Discussion of histopathology","volume":"14","author":"Stevenson LD","year":"1930","journal-title":"Med Clin North Am"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1943.02290230064007"},{"key":"e_1_2_1_9_2","first-page":"1036","article-title":"Case of primary reticulum cell sarcoma of brain; relationship of microglial cells to histiocytes","volume":"26","author":"Yuile CL","year":"1938","journal-title":"Arch Pathol"},{"key":"e_1_2_1_10_2","first-page":"387","article-title":"Case of primary reticuloendothelioma of central nervous system","volume":"21","author":"Ferens E","year":"1938","journal-title":"Neurol Polska"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1943.02290190053005"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/71.1.1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195007000-00006"},{"key":"e_1_2_1_14_2","first-page":"943","article-title":"A propose d'une observation d'encephalito granulomateuse reticulo\u2010histiocytaire","volume":"60","author":"Brucher JM","year":"1960","journal-title":"Acta Neurol Psychiatr Belg"},{"key":"e_1_2_1_15_2","first-page":"141","article-title":"A comparison of die fine structure of malignant lymphomas and other neoplasms of the brain","volume":"6","author":"Hirano A","year":"1975","journal-title":"Acta Neuropathol Suppl"},{"key":"e_1_2_1_16_2","first-page":"606","article-title":"Primary reticulum cell sarcoma (microglioma) of the brain. 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