{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:38:49Z","timestamp":1792147129933,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":7231,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A review of all primary hepatic tumors seen at Children's Hospital, Boston over a 57\u2010year period disclosed six cases of focal nodular hyperplasia (FNH) and two hepatic adenomas (HA). The children with FNH (four females, two males) ranged in age from 6 months to 15 years (average age: 7 years). Three patients had \u201chepatomegaly\u201d noted on physical examination 2 months to 2 or more years prior to diagnosis. The average diameter of FNH was 7.3 cm (range 2.5\u201010 cm). The lesion was confined to the right lobe in four cases and showed bilobar involvement in two. The HA's were diagnosed in a newborn male and a 2\u2010year\u2010old girl, both of whom were symptomatic because of large tumor size (10 cm each). There was no maternal history of exposure to exogenous steroids during pregnancy. Three children with FNH underwent hepatic lobectomy and were alive and well 4 to 17 years later. One child who died of acute leukemia had an incidental FNH discovered at autopsy. Two patients were treated conservatively with biopsy only and were alive and symptom\u2010free 13 and 15 years later. Both children with HA underwent hepatic lobectomy. One died postoperatively because of intra\u2010abdominal hemorrhage and the other was alive and well 101A years later. Complete surgical resection is recommended for most children with HA when technically feasible because of 1) the lingering suspicion of possible (albeit remote) malignant transformation and 2) diagnostic difficulties in distnguishing HA from a well\u2010differentiated hepatocellular carcinoma.<\/jats:p>","DOI":"10.1002\/jso.2930330217","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T10:48:09Z","timestamp":1171968489000},"page":"129-135","source":"Crossref","is-referenced-by-count":27,"title":["Focal nodular hyperplasia and hepatic adenoma: A review of eight cases in the pediatric age group"],"prefix":"10.1002","volume":"33","author":[{"given":"Ernest E.","family":"Lack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Ornvold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198212000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1510::AID-CNCR2820520830>3.0.CO;2-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)92594-4"},{"key":"e_1_2_1_5_2","first-page":"217","article-title":"Hepatic tumors in the pediatric age group: A distinctive clinicopathologic spectrum","volume":"4","author":"Dehner LP","year":"1978","journal-title":"Perspect Pediatr Pathol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1970.01340260149024"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/60.4.512"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(75)90095-0"},{"key":"e_1_2_1_9_2","first-page":"205","volume-title":"Hepatocellular Carcinoma","author":"Landing BH","year":"1976"},{"key":"e_1_2_1_10_2","volume-title":"Tumors of the liver and intrahepatic bile ducts","author":"Edmondson HA","year":"1958"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195307)6:4<743::AID-CNCR2820060413>3.0.CO;2-F"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810715)48:2<336::AID-CNCR2820480220>3.0.CO;2-S"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(76)80101-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197701010-00004"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(80)80142-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0037-198X(83)90005-6"},{"key":"e_1_2_1_17_2","first-page":"85","article-title":"Focal nodular hyperplasia and adenoma of the liver. A pediatric experience","volume":"1","author":"Dehner LP","year":"1979","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31998-8"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/70.1.6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03300070040020"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602262940904"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80087-4"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03270140033019"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1761::AID-CNCR2820400454>3.0.CO;2-C"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1765::AID-CNCR2820400455>3.0.CO;2-Y"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1759::AID-CNCR2820400453>3.0.CO;2-T"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(77)80022-1"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930330217","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930330217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T18:26:14Z","timestamp":1697826374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930330217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,10]]}},"alternative-id":["10.1002\/jso.2930330217"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930330217","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,10]]}}}