{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T01:21:44Z","timestamp":1697937704261},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":7170,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010seven patients with squamous cell carcinoma of the mobile tongue and floor of the mouth were treated with external beam and interstitial radiation. Good prognostic factors were T<jats:sub>1<\/jats:sub>N<jats:sub>0<\/jats:sub>, T<jats:sub>2<\/jats:sub>N<jats:sub>0<\/jats:sub>, superficial tumors, tumor shrinkage by 75% with external beam, and no apparent tumor clinically 2 months after treatment. On the other hand, T<jats:sub>3<\/jats:sub>N<jats:sub>0<\/jats:sub>, T<jats:sub>1\u20103<\/jats:sub>N<jats:sub>1<\/jats:sub>, and deeply necrotic tumors had a poor prognosis. We recommend using a flexible afterloading system to implant the initial local tumor volume (not just the residual nidus) that does not exceed 45 cm<jats:sup>3<\/jats:sup>. The minimum (reference) dose was prescribed to a surface 1\/2 cm beyond the most peripheral rim of radioactive sources. For acceptable local control and complication rates, our suggested minimum (reference) doses are \u2a7d7,500 rads for T<jats:sub>1<\/jats:sub> (or a time\u2010dose\u2010fractionation [TDF] of 131\u2010140), &lt;8,000 rads for T<jats:sub>2<\/jats:sub> (TDF of 131\u2010140), and probably &lt; 8,500 rads for T<jats:sub>3<\/jats:sub> (TDF of \u2a7d 150). These guidelines should be considered preliminary.<\/jats:p>","DOI":"10.1002\/jso.2930330415","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T10:43:39Z","timestamp":1171968219000},"page":"273-283","source":"Crossref","is-referenced-by-count":5,"title":["Proposed method to study the factors affecting local control with combined external beam and interstitial implantation of mobile tongue and floor of mouth"],"prefix":"10.1002","volume":"33","author":[{"given":"Brace L.","family":"Hintz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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