{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:39:49Z","timestamp":1760981989092},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":7049,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two hundred fifty patients with distant metastasis from malignant melanoma were analyzed at the first appearance of systemic metastasis. Commonly involved sites were lung, subcutaneous tissue, brain, and liver. Frequency of liver metastasis was higher with eye and mucous membrane primary sites (P &lt; 0.01). Liver involvement had the worse survival compared to lung and brain. Patients with mucosal or unknown primary sites had decreased survival compared to other sites (P &lt; 0.01). Patients with primary melanomas thicker than 4 mm had significantly shorter survival (P &lt; 0.02). Single\u2010organ involvement correlated with ionger survival compared to multiple\u2010organ involvement (P &lt; 0.04). Survival of metastatic disease was more favorable in patients with involvement of subcutaneous tissue only and in those with a disease\u2010free interval of 2 years or longer. Five\u2010year survival from first appearance of metastasis was 7% and median survival was 8 months.<\/jats:p>","DOI":"10.1002\/jso.2930340407","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:20:26Z","timestamp":1171970426000},"page":"248-252","source":"Crossref","is-referenced-by-count":22,"title":["Early metastatic patterns and survival in malignant melanoma"],"prefix":"10.1002","volume":"34","author":[{"given":"Raman N.","family":"Nambisan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Alexiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Reese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine P.","family":"Karakousis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"e_1_2_1_3_2","first-page":"705","article-title":"The histogenesis and biologic behavior of primary human malignant melanomas of the skin","volume":"29","author":"Clark WH","year":"1969","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197711000-00016"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821015)50:8<1656::AID-CNCR2820500833>3.0.CO;2-L"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90171-X"},{"key":"e_1_2_1_7_2","first-page":"1823","volume-title":"Cancer Medicine","author":"Luce JK","year":"1973"},{"key":"e_1_2_1_8_2","volume-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch JD","year":"1980"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830715)52:2<334::AID-CNCR2820520225>3.0.CO;2-E"},{"key":"e_1_2_1_10_2","first-page":"1995","article-title":"Prognostic correlations and response to treatment in advanced metastatic malignant melanoma","volume":"34","author":"Einhorn LH","year":"1974","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_2","first-page":"687","article-title":"Clinical presentation, natural history and prognostic factors in advanced malignant melanoma","volume":"149","author":"Amer MH","year":"1979","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1983.1.2.126"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830801)52:3<575::AID-CNCR2820520333>3.0.CO;2-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831001)52:7<1342::AID-CNCR2820520733>3.0.CO;2-C"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930340407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930340407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T18:55:07Z","timestamp":1697914507000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930340407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["10.1002\/jso.2930340407"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930340407","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}