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The pleomorphic tumor is positive for keratin and \u03b1<jats:sub>1<\/jats:sub>\u2010antitrypsin by immunohistochemistry, has intracellular lumina by electron microscopy, a moderately high thymidine labeling index, and is negative for estrogen and progesterone receptors. A review of the literature concerning liver tumors occurring in young patients indicates that there is an underlying disturbance of the hormonal milieu in all instances reported. The prognosis is widely variable and unpredictable.<\/jats:p>","DOI":"10.1002\/jso.2930350307","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:16:22Z","timestamp":1171970182000},"page":"173-179","source":"Crossref","is-referenced-by-count":9,"title":["Hepatic adenoma within a spindle cell carcinoma in a woman with a long history of oral contraceptives"],"prefix":"10.1002","volume":"35","author":[{"given":"P.","family":"Grigsby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A.","family":"Sicard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Huggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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