{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:41:01Z","timestamp":1782549661718,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":6896,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Somatostatinomas are rare endocrine tumors that were first described in 1977. In addition to the present case report, there have been 31 cases reported in the literature. We have reviewed the literature to integrate the symptoms, physical findings, diagnostic tests, treatment, and length of survival of these patients. Although the symptoms that occurred in the majority of cases were those that are seen in most patients with intra\u2010abdominal neoplasms, symptoms relating to the presence of excess circulating somatostatin\u2014diabetes, maldigestion, and cholelithiasis\u2014were frequently seen. Physical findings and the results of diagnostic tests were usually nonspecific. The majority of the patients underwent radical surgical procedures (Whipple procedure or pancreatic resection). The pancreas was the most frequent site of involvement (21\/31 cases), but primaries in the duodenum, ampulla of Vater, cystic duct, and jejunum have been described as well. Metastases were most frequently seen in the liver and lymph nodes. Chemotherapeutic agents were administered to 10 patients, usually as adjuvant therapy, and appear to be useful in treating recurrent and metastatic disease. The one\u2010year survival of these patients is 48%, which is better than that for patients with carcinoma of the pancreas or biliary tree. Therefore, it is important that the diagnosis of somatostinoma be made so that the patient may be treated accordingly and followed by serial somatostatin levels for evidence of metastasis or recurrent disease.<\/jats:p>","DOI":"10.1002\/jso.2930360104","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:13:24Z","timestamp":1171970004000},"page":"8-16","source":"Crossref","is-referenced-by-count":57,"title":["Somatostatinoma: A case report and review of the literature"],"prefix":"10.1002","volume":"36","author":[{"given":"Gary J.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin","family":"Tio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Anatolio B.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4068.77"},{"key":"e_1_2_1_3_2","first-page":"27","article-title":"The APUD concept and its implications in pathology","volume":"9","author":"Pearse AG","year":"1974","journal-title":"Pathol Annu"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92113-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197704282961703"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92578-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427182"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.133.5.939"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197908093010601"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-4-572"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<2273::AID-CNCR2820440641>3.0.CO;2-U"},{"key":"e_1_2_1_12_2","volume-title":"Hypoglycemia","author":"Marks V","year":"1979"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1980.tb01382.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1980.tb01383.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0016-5085(19)30519-0","article-title":"Calcitonin producing pancreatic somatostatinoma","volume":"78","author":"Galmiche JP","year":"1980","journal-title":"Gastroenterology"},{"issue":"3","key":"e_1_2_1_16_2","first-page":"309","article-title":"Glucose turnover and gluco\u2010neogenesis in a patient with somatostatinoma","volume":"89","author":"Lowry SF","year":"1981","journal-title":"Surgery"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-52-5-886"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6355.1618"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0016-5085(83)80090-0","article-title":"A case of duodenal somatostatinoma: Diagnostic usefulness of calcium\u2010pentagastrin test","volume":"85","author":"Somers G","year":"1983","journal-title":"Gastroenterology"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198310000-00006"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-56-6-1236"},{"issue":"1","key":"e_1_2_1_22_2","first-page":"153","article-title":"Duodenal Somatostatinoma. 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