{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T23:10:01Z","timestamp":1736809801484,"version":"3.33.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":6805,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1987,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Records of 215 patients receiving radical mastectomies from 1958 to 1968 at Roswell Park Memorial Institute were reviewed for the significance of axillary nodal status on long\u2010term survival and recurrence. Ten\u2010year disease\u2010free interval rates were 83%, 47%, and 17%, respectively, for patients with negative nodes, 1\u20133 positive nodes, and \u2265 4 positive nodes. Fifteen\u2010year rates were 80%, 37%, and 8%, respectively. Survival and disease\u2010free interval curves for the 3 nodal status groups were significantly different from each other (P&lt;0.0001). Curves for three subclasses of the \u2265 4 positive node group (4\u20136, 7\u201312, and \u2265 13) were similar in overall survival, but were significantly (P=0.04) different for disease\u2010free interval, due to a rapid rate of recurrence in the \u2265 13 positive node group. Hazard rates of treatment failure during each successive 3\u2010year period for 9 years following mastectomy for those with 1\u20133 positive nodes or \u2265 4 positive nodes decreased with time, whereas the rates for those with negative nodes were low and relatively constant throughout follow\u2010up. These findings support the thesis that a significant proportion of negative nodes patients are cured by mastectomy and that a smaller group of node\u2010positive patients have regional disease with a chance of cure by mastectomy.<\/jats:p>","DOI":"10.1002\/jso.2930360406","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:33:55Z","timestamp":1171971235000},"page":"243-248","source":"Crossref","is-referenced-by-count":15,"title":["Effect of axillary nodal status on the long\u2010term survival following mastectomy for breast carcinoma: Nodal metastases may not always suggest systemic disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Jung Hyun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson H.","family":"Slack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Nemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800615)45:12<2917::AID-CNCR2820451203>3.0.CO;2-M"},{"key":"e_1_2_1_3_2","first-page":"337","article-title":"Surgical adjuvant chemotherapy in cancer of the breast: Results of a decade of cooperative investigation","volume":"168","author":"Fisher B","year":"1960","journal-title":"Am Surg"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life\u2010tables","volume":"34","author":"Cox DR","year":"1972","journal-title":"J R Stat Soc B"},{"key":"e_1_2_1_6_2","first-page":"12","volume-title":"Statistical Methods For Survival Data Analysis","author":"Lee ET","year":"1980"},{"key":"e_1_2_1_7_2","first-page":"79","article-title":"Number of lymph nodes examined and the prognosis of breast carcinoma","volume":"131","author":"Fisher B","year":"1970","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197404)33:4<1145::AID-CNCR2820330438>3.0.CO;2-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3 <685::AID-CNCR2820531316>3.0.CO;2-P"},{"key":"e_1_2_1_10_2","first-page":"527","article-title":"Carcinoma of the breast, analysis of total lymph node involvement vs","volume":"39","author":"Smith J","year":"1977","journal-title":"Level of metastasis. 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