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IORT can induce a progressive retroperitoneal fibrosis and fibrosis of the porta hepatis in patients with resectable pancreatic carcinoma. In unresectable pancreatic carcinoma, the major expression of intraoperative irradiation with external beam irradiation is a progressive fibrosis of the pancreas with vascular sclerosis, nerve degeneration, atrophy of acinar cells, and atypical changes in the ducts of the pancreas, as well as degenerative changes of the pancreatic tumor.<\/jats:p>","DOI":"10.1002\/jso.2930370208","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:31:53Z","timestamp":1171971113000},"page":"104-108","source":"Crossref","is-referenced-by-count":25,"title":["Histopathological effects of intraoperative radiotherapy on pancreas and adjacent tissues: A postmortem analysis"],"prefix":"10.1002","volume":"37","author":[{"given":"Harald J.","family":"Hoekstra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Kinsella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Sindelar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197603)37:3<1519::AID-CNCR2820370340>3.0.CO;2-O"},{"key":"e_1_2_1_3_2","first-page":"691","volume-title":"Cancer. 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