{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:53:40Z","timestamp":1774662820660,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":6561,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two cases of lymphangiosarcoma arising in a chronic lymphedematous extremity following mastectomy (Stewart\u2010Treves syndrome) were reported with not only standard histology, but also special study on the ultrastructure and immunohistology. These cancers developed as a result of chronic lymphedema of the involved limb following mastectomy 15 and 16 years ago, respectively, for breast carcinoma. Immunohistologic and electron microscopic examinations proved that this tumor originates in the vascular endotheliocytes, even though they are clinically chronic lesions apparently derived from the lymphatic vessels. This sarcoma develops multicentrically in an edematous arm and spreads out rapidly, so prognosis is quite discouraging in those patients. They need to be radically surgically treated without hesitation; hence, amputation, not limb\u2010saving surgery, should be indicated.<\/jats:p>","DOI":"10.1002\/jso.2930380415","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:24:59Z","timestamp":1171970699000},"page":"275-282","source":"Crossref","is-referenced-by-count":45,"title":["Lymphangiosarcoma in postmastectomy lymphedema (Stewart\u2010Treves syndrome): Ultrastructural and immunohistologic characteristics"],"prefix":"10.1002","volume":"38","author":[{"given":"Katsuro","family":"Tomita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Yokogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Oda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Terahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194805)1:1<64::AID-CNCR2820010105>3.0.CO;2-W"},{"key":"e_1_2_1_3_2","first-page":"527","article-title":"One of the cases of Stewart\u2010Treves syndrome and the results of immunohistochemical and electron microscopic examinations","volume":"26","author":"Setoyama H","year":"1948","journal-title":"Dermatol Clin"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004619804"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197208)30:2<562::AID-CNCR2820300237>3.0.CO;2-V"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811001)48:7<1674::AID-CNCR2820480733>3.0.CO;2-H"},{"key":"e_1_2_1_7_2","first-page":"602","volume-title":"Tumors of the soft tissues","author":"Das Gupta TK","year":"1983"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1979.01370250084018"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1960.tb23186.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700850225"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197101)27:1<100::AID-CNCR2820270115>3.0.CO;2-0"},{"key":"e_1_2_1_12_2","first-page":"586","article-title":"Postmastectomy lymphangiosarcoma: experience with three patients and electron microscopic observations in one","volume":"22","author":"Unruh H","year":"1979","journal-title":"Can J Surg"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1985.tb02451.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.23.1.101"},{"key":"e_1_2_1_15_2","first-page":"377","article-title":"Endothelial cells and the biology of factor VIII","volume":"286","author":"Jaffe EA","year":"1977","journal-title":"N Engl J Med"},{"key":"e_1_2_1_16_2","first-page":"515","article-title":"Immunoperioxidase localization of Factor VIII in angiosarcomas","volume":"106","author":"Guarda LA","year":"1982","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.121.6.742"},{"key":"e_1_2_1_18_2","first-page":"43","article-title":"Post\u2010mastectomy angiosarcoma: case report and review of the literature","volume":"80","author":"Smith L","year":"1984","journal-title":"Tex Med"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930380415","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930380415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T20:24:16Z","timestamp":1698006256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930380415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,8]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,8]]}},"alternative-id":["10.1002\/jso.2930380415"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930380415","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,8]]}}}