{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:28:05Z","timestamp":1761290885127},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":6439,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1988,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to investigate the lethality of carcinoma of the gallbladder and several of the coexisting features, a retrospective analysis of 53 patients with this disease was undertaken. Abdominal pain, obstructive jaundice, and a right upper quandrant mass were present in approximately one\u2010half of the patients. Laboratory and radiological data were frequently nonspecific and did little to identify the diagnosis. The most common preoperative diagnoses were cholelithiasis or chronic cholecystitis. Cholecystectomy was the most frequently performed procedure. Fifteen wedge liver resections were performed. No radical or extended liver resections were done. Eighty\u2010one percent of the patients had sufficient data for staging. Five patients (11.6%) had stage I lesions, three patients (7.0%) had stage II lesions, while 17 (39.5%) and 18 (41.9%) patients had stage III and IV lesions, respectively. Mean survival was 6.4 months for the entire group. Three patients are still alive (two longer than 5 years and one at 2 years) for an overall survival of 5.7%. Both staging and grading of the tumor correlated well with patient survival. Those patients with stage I lesions survived significandy longer (23 months vs. 3 months) than those with stage IV tumors. Also, those with more favorably graded (well\u2010differentiated) neoplasms lived an average of 13 months longer than patients with poorly differentiated lesions.<\/jats:p>","DOI":"10.1002\/jso.2930390407","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:44:30Z","timestamp":1171971870000},"page":"251-255","source":"Crossref","is-referenced-by-count":31,"title":["Primary carcinoma of the gallbladder: TNM staging and prognosis"],"prefix":"10.1002","volume":"39","author":[{"given":"Keith","family":"White","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Kraybill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin J.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Rationis Medendi in Nosocomio Practice Unindobonensi","author":"DeStoll M","year":"1977"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90049-6"},{"key":"e_1_2_1_4_2","first-page":"929","article-title":"Primary carcinoma of the gallbladder","volume":"147","author":"Piehler JM","year":"1978","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_5_2","volume-title":"Manual for staging of cancer 1978","author":"American Joint Committee for Cancer Staging and End Results Reporting","year":"1978"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197807)42:1<330::AID-CNCR2820420150>3.0.CO;2-F"},{"key":"e_1_2_1_7_2","unstructured":"WarrenK HardyK O'RourkeM: Primary neoplasia of the gallbladder.Surg Gynecol Obstet1036\u20131040 1968."},{"key":"e_1_2_1_8_2","first-page":"368","article-title":"Primary carcinoma of the gallbladder","volume":"47","author":"Strauch GO","year":"1960","journal-title":"Surgery"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195701000-00019"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194905)2:3<379::AID-CNCR2820020303>3.0.CO;2-Q"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.7.5.433"},{"key":"e_1_2_1_12_2","first-page":"55","article-title":"Clinical management of advanced gastrointestinal cancer","volume":"3","author":"Moertel CG","year":"1973","journal-title":"Semin Drug Treat"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90641-9"},{"key":"e_1_2_1_14_2","first-page":"418","article-title":"Primary malignant tumors of the gallbladder: Report of 43 cases","volume":"67","author":"Tanga MR","year":"1970","journal-title":"Surgery"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196207000-00021"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197601)37:1<141::AID-CNCR2820370121>3.0.CO;2-Y"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930210404"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198205000-00012"},{"key":"e_1_2_1_19_2","first-page":"709","article-title":"Primary gallbladder carcinoma: Significance of subserosal lesions and results of aggressive surgical treatment and adjuvant chemotherapy","volume":"94","author":"Marrow CE","year":"1983","journal-title":"Surgery"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930390407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930390407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:23:42Z","timestamp":1697977422000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930390407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,12]]}},"alternative-id":["10.1002\/jso.2930390407"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930390407","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12]]}}}