{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T07:05:51Z","timestamp":1768633551318,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":6318,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Forty\u2010one patients with marginally resectable stage III M<jats:sub>0<\/jats:sub> non\u2010small cell lung cancer (NSCLC) were entered into a study evaluating neoadjuvant cyclophosphamide, adriamycin, and cisplatin chemotherapy (CAP) followed by radiotherapy and subsequent resection. Postoperative radiotherapy and additional CAP were also administered. The objective disease regression rate prior to surgery was 72% (2 complete, 12 partial, and 7 minimal responses). Thoracotomy was carried out in 37 patients (90%), with resection of all gross disease in 36 patients (97%). Relapse occurred in 22 (61%) of the resected patients, involving chest only (four patients), chest and extra thoracic (nine patients), and extra thoracic only (nine patients). Subsequent CNS relapse developed in 9 (25%) of 36 postop patients in association with other sites of relapse (five patients) or as a solitary location (four patients). Only one of seven patients receiving prophylactic cranial irradiation (PCI) developed CNS relapse compared with 7 (26%) of 27 patients not receiving PCI. The median long\u2010term follow\u2010up for 14 living patients is 53 + months, with a range of 38 + to 71 + months. Median survival for all patients is 32 months, with 1\u2010year survival being 75%. The survival curve shows a plateau of 31% from 3 to 5 + years. Using a log rank test, no prognostic subgroups could be identified that significantly affected response rate, disease\u2010free survival, or overall survival. While neoadjuvant CAP followed by radiotherapy appears to improve survival, more effective chemotherapy along with randomized studies are needed to determine the role of initial chemotherapy in marginally resectable NSCLC.<\/jats:p>","DOI":"10.1002\/jso.2930400413","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:41:42Z","timestamp":1171971702000},"page":"266-274","source":"Crossref","is-referenced-by-count":126,"title":["Neoadjuvant chemotherapy in marginally resectable stage III M<sub>0<\/sub> non\u2010small cell lung cancer: Long\u2010term follow\u2010up in 41 patients"],"prefix":"10.1002","volume":"40","author":[{"given":"Arthur","family":"Skarin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxine","family":"Jochelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Sheldon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Malcolm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Oliynyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Overholt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myla","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Emil","family":"Frei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"333","article-title":"Is immediate radiation therapy indicated for patients with unresectable non\u2010cell lung cancer?","volume":"67","author":"Cohen MH","year":"1983","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)64249-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)63881-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<914::AID-CNCR2820360312>3.0.CO;2-Q"},{"key":"e_1_2_1_6_2","first-page":"865","article-title":"Results of surgical treatment of carcinoma of the lung by stage and cell type","volume":"147","author":"Kemeny MM","year":"1978","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)64250-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197805)41:5<2040::AID-CNCR2820410552>3.0.CO;2-I"},{"key":"e_1_2_1_9_2","first-page":"587","article-title":"Combination chemotherapy followed by radiation therapy in patients with regional stage III unresectable non\u2010small cell lung cancer","volume":"69","author":"Fram R","year":"1985","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_10_2","first-page":"127","volume-title":"Primary Chemotherapy in Cancer Medicine","author":"Skarin A","year":"1985"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1983.1.11.710"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821115)50:10<1979::AID-CNCR2820501002>3.0.CO;2-D"},{"key":"e_1_2_1_13_2","first-page":"67","volume-title":"The Concepts of Neoadjuvant Chemotherapy. 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