{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:12:41Z","timestamp":1697976761389},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":6227,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The polyamine biosynthesis inhibitor D,L\u2010\u03b1\u2010Difluoromethylornithine hydrochloride monohydrate (DFMO) has cytostatic and cytotoxic effects against various human tumor cell lines in vitro. We measured levels of the polyamines putrescine and spermidine in the urine of cancer patients undergoing \u201cconventional\u201d chemotherapy in a two\u2010arm randomized phase I\u2013II study with and without additional DFMO administered orally at a dose of 1.7 g\/sq.m. t.i.d. The study group included 38 patients with carcinoma of the breast, stomach, prostate, or female genital organs or metastatic carcinoma of unknown origin. A control group of 32 patients with similar malignancies received \u201cconventional\u201d chemotherapy without DFMO. Polyamine levels were determined periodically in the urine of all patients. In DFMO\u2010treated patients, a significant decrease in putrescine and spermidine levels was observed after 3 weeks of DFMO therapy (the first time point evaluated) that usually persisted throughout the course of treatment. Significant differences in polyamine levels between DFMO\u2010treated and control patients were observed for patients in remission. Less significant differences were noted, however, for patients with static or progressive disease between DFMO\u2010treated and control groups. DFMO activity appears to be reflected by a long\u2010term decrease in urinary polyamine levels.<\/jats:p>","DOI":"10.1002\/jso.2930410309","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:39:51Z","timestamp":1171971591000},"page":"177-182","source":"Crossref","is-referenced-by-count":1,"title":["Urinary polyamine levels in cancer patients treated with D,L\u2010\u03b1\u2010Difluoromethylornithine, an inhibitor of polyamine biosynthesis"],"prefix":"10.1002","volume":"41","author":[{"given":"Yoav","family":"Horn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Spigel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence 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of 1,3\u2010bis(2\u2010chloroethyl)\u20101\u2010nitrosourea cytotoxicity by alpha\u2010difluoromethylornithine in 9L rat brain tumor spheroids","volume":"44","author":"Sano Y","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6186025"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6950518"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.4.2355"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(78)91630-3"},{"key":"e_1_2_1_12_2","first-page":"214","article-title":"Polyamines as markers of response and disease activity in cancer chemotherapy","volume":"37","author":"Durie BGM","year":"1977","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9269-3_25"},{"key":"e_1_2_1_14_2","first-page":"3248","article-title":"Further evidence for the use of polyamines as biochemical markers for malignant tumors","volume":"42","author":"Horn Y","year":"1982","journal-title":"Cancer Res"},{"key":"e_1_2_1_15_2","first-page":"4675","article-title":"Relationship of urinary polyamines to tumor activity and tumor volume in patients","volume":"44","author":"Horn Y","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254263"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(87)90141-6"},{"key":"e_1_2_1_18_2","first-page":"890","article-title":"Decarboxylated\u2010S\u2010adenosylmethionine excretion: A biochemical marker of ornithine decarboxylase inhibition by alpha\u2010difluoromethylornithine","volume":"47","author":"Haegele KD","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1984.2.2.124"},{"key":"e_1_2_1_20_2","first-page":"993","article-title":"Predictive value of cerebrospinal fluid polyamines in medulloblastoma","volume":"39","author":"Marton LJ","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_21_2","first-page":"464","volume-title":"Introduction to Statistical Analysis","author":"Dixon WJ","year":"1969"}],"container-title":["Journal of Surgical 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