{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:11:16Z","timestamp":1698066676837},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":6135,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine whether or not the cytotoxic effects of hyperthermia are directed primarily to malignant cells, we examined changes in thermosensitivity during hepatocarcinogenesis in rats, as induced by 3\u2032\u2010methyl\u20104\u2010dimethylaminoazobenzene (3\u2032\u2010Me\u2010DAB). The findings were compared with those in livers of rats fed a commercial diet. The cell viability was determined using the succinate dehydrogenase inhibition (SDI) test. The succinate dehydrogenase (SD) activity of liver cells, when exposed to heat (43\u00b0C) for 2, 5, or 10 hr, decreased in a time\u2010dependent manner, in each tissue. The decrease in SD activity was evident in 3\u2032\u2010Me\u2010DAB liver for 5 hr of heat treatment on day 57, compared with findings in the normal liver. Significant differences were present for 2, 5, and 10 hr on days 93 and 136. Thus a chemically induced hepatoma is more sensitive to heat than are the normal cells. As this thermosensitivity gradually increased during the hepatocarcinogenesis, the malignant cells are particularly vulnerable to hyperthermia.<\/jats:p>","DOI":"10.1002\/jso.2930420207","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:51:08Z","timestamp":1171972268000},"page":"99-102","source":"Crossref","is-referenced-by-count":0,"title":["Azo\u2010dye\u2010induced primary hepatoma and a gradual increase in thermosensitivity"],"prefix":"10.1002","volume":"42","author":[{"given":"Tetsuya","family":"Kusumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Maehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kusumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Sugimachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_1_2","first-page":"469","article-title":"Reproductive capacity and viability at higher temperatures of various transformed hamster cell lines","volume":"43","author":"Kachaniz Z","year":"1967","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_2_2","first-page":"4507","article-title":"Comparative studies of heat sensitivity of several rat hepatoma cell lines and hepatocytes in primary culture","volume":"44","author":"Schamhart D","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089167906500409"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.2307\/3573947"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(69)90059-0"},{"key":"e_1_2_1_6_2","first-page":"3944","article-title":"Selective lethal effect of supranormal temperatures on human neoplastic cancers","volume":"36","author":"Gisvanella B","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_2","first-page":"3967","article-title":"Heat shock protein synthesis and cell survival in clones of normal and SV 40\u2010transformed mouse embryo cells","volume":"44","author":"Omar R","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(88)90259-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1980.tb50751.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2307\/3576432"},{"key":"e_1_2_1_11_2","first-page":"258","article-title":"Rapid loss of stress fibers in Chinese hamster ovary cells after hyperthermia","volume":"45","author":"Glass J","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(69)90060-7"},{"key":"e_1_2_1_13_2","first-page":"3","article-title":"Heat induced cell death and radiosensitization","volume":"61","author":"Roti Roti JL","year":"1980","journal-title":"J Natl Cancer Inst Monogr"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000226530"},{"key":"e_1_2_1_15_2","first-page":"203","article-title":"Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma","volume":"13","author":"Maehara Y","year":"1987","journal-title":"Eur J Surg Oncol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","unstructured":"HiramotoY KusumotoT MaeharaY SakaguchiY KidoY IshidaT SugimachiK: Sarcoma\u2010180 cells are more sensitive to heat than are mouse normal tissues: esophagus stomach small intestine large intestine liver spleen kidney.J Surg Oncolin press 1989.","DOI":"10.1002\/jso.2930400307"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01893253"},{"key":"e_1_2_1_18_2","first-page":"2573","article-title":"Experimental hepatocellular carcinogenesis","volume":"36","author":"Newberne PM","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(80)90002-5"},{"key":"e_1_2_1_20_2","first-page":"167","article-title":"The pathogenesis of rat liver cancer caused by chemical carcinogenesis","volume":"605","author":"Williams GM","year":"1980","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_1_21_2","first-page":"168","article-title":"Hepatocarcinomas, cholangiocarcinomas, and hepatoblastomas produced by chemically transformed cultured rat epithelial cells. 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