{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T11:23:31Z","timestamp":1698060211071},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":6104,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ornithine decarboxylase (ODC) catalyzes the formation of putrescine from ornithine, which is the first step in the pathway of mammalian polyamine biosynthesis. Tissue activity levels of ODC have been suggested to be a marker of risk for colorectal cancer in hereditary polyposis and in adenoma formers. We analyzed ODC activity in rectal and sigmoid colon mucosal biopsies obtained at 10 cm and at 30 cm in 40 healthy, colon cancer risk factor\u2010free adults following three endoscopic preparation regimens: (1) no special preparation; (2) two phosphate enemas; and (3) \u201cColyte\u201d lavage preparation 12 hr previously. Levels of ODC, measured in fresh tissue, were approximately twofold higher for enema preparation vs. no preparation (for log\u2010transformed data: sigmoid, <jats:italic>P<\/jats:italic> &lt; 0.0001; rectum, <jats:italic>P<\/jats:italic> = 0.0001) and for enema preparation vs. lavage (sigmoid, <jats:italic>P<\/jats:italic> = 0.0002; rectum, <jats:italic>P<\/jats:italic> = 0.008). Lavage and no preparation ODC levels were not significantly different. ODC activity levels ranged from 0.00 to 352.96 pmol\/mg\/hr.<\/jats:p>","DOI":"10.1002\/jso.2930420304","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:51:03Z","timestamp":1171972263000},"page":"150-153","source":"Crossref","is-referenced-by-count":8,"title":["Colon ornithine decarboxylase activity following standard endoscopy preparation regimens"],"prefix":"10.1002","volume":"42","author":[{"given":"Richard R.","family":"Love","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit K.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya S.","family":"Surawicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Morrissey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198407123110210"},{"key":"e_1_2_1_3_2","first-page":"2644","article-title":"The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis","volume":"36","author":"O'Brien TG","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198407123110202"},{"key":"e_1_2_1_5_2","unstructured":"LukGD DesaiT BullA et al.: Rectal mucosal ornithine decarboxylase activity as a marker for colonic polyps and cancers.Gastroenterology94 Part 2 Abstract 273 1988."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930380407"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740513"},{"key":"e_1_2_1_8_2","unstructured":"ProtellRL TrippMR MorganTR et al.:Can ornithine decarboxylase (ODC) levels presage adenoma\u2010prone mucosa?Abstract presented at Western Section Meeting American Federation for Clinical Research Carmel California February 4\u20137 1986."}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930420304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930420304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T02:52:53Z","timestamp":1696733573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930420304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1002\/jso.2930420304"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930420304","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}