{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T11:25:34Z","timestamp":1698060334771},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":6013,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tissue activity levels of ornithine decarboxylase (ODC) have been suggested to be a marker of colonic epithelial cell proliferation and risk for colorectal cancer. Supplemental dietary calcium has been hypothesized and reported to suppress colonic epithelial\u2010cell proliferation. We measured sigmoid and rectal mucosal ODC activity levels in 45 healthy, disease\u2010free subjects with strong family histories of colorectal cancer before and after 2 months, during which daily dietary supplementation with calcium carbonate (to provide 600 mg calcium base) was taken. Although the mean ODC activity levels decreased in both sigmoid and rectal specimens, these changes were small in relation to the standard deviation and were not statistically significant. These data suggest that the magnitude of dietary calcium intake does not significantly influence sigmoid\u2010rectal mucosal ODC activity levels and that ODC measurements may not be a useful intermediate endpoint for interventions designed to interrupt the colon carcinogenic sequence.<\/jats:p>","DOI":"10.1002\/jso.2930430204","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:47:35Z","timestamp":1171972055000},"page":"79-82","source":"Crossref","is-referenced-by-count":3,"title":["Absence of effect of supplemental oral calcium on ornithine decarboxylase (ODC) activity in colonic mucosae of healthy individuals with a family history of colorectal cancer"],"prefix":"10.1002","volume":"43","author":[{"given":"Richard R.","family":"Love","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit K.","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya S.","family":"Surawicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Morrissey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Cancer mortality for selected sites in 24 countries No. 6 (1966\u20131967)","author":"Segi M","year":"1972"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000414759"},{"key":"e_1_2_1_4_2","first-page":"1323","article-title":"Colon cancer and dietary fat, phosphate and calcium: A hypothesis","volume":"72","author":"Newmark HL","year":"1984","journal-title":"JNCI"},{"key":"e_1_2_1_5_2","first-page":"4201","article-title":"Classification and risk assessment of individuals with familial polypous, Gardner's syndrome, and familial non\u2010polyposis colon cancer from [3]thymidine labelling patterns in colonic epithelial cells","volume":"44","author":"Lipkin M","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197502)35:2<413::AID-CNCR2820350217>3.0.CO;2-B"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198407123110202"},{"key":"e_1_2_1_8_2","article-title":"Rectal mucosal ornithine decarboxylase activity as a market for colonic polyps and cancers","volume":"94","author":"Luk GD","year":"1988","journal-title":"Gastreonterology"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930380407"},{"key":"e_1_2_1_10_2","first-page":"5426","article-title":"Inhibition of human colonic epithelial cell proliferation invivo and invitro by calcium","volume":"46","author":"Buset M","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511283132203"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1977.01370020064007"},{"key":"e_1_2_1_13_2","first-page":"311","article-title":"The cancer family syndrome: A status report","volume":"24","author":"Lynch NT","year":"1981","journal-title":"Dis Colon Rectum"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1300\/J077v03n03_02"},{"key":"e_1_2_1_15_2","unstructured":"GregareRC SternHS YoungKS et al.:Effect of calcium supplementation on mucosal cell proliferation in high risk patients for colon cancer. 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