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The patient presented with symptoms of general malaise, anorexia, weight loss, mild diarrhea, and borderline diabetes mellitus, although there was no cholelithiasis. The diagnosis remained unclear until immunohistochemical studies of the resected specimen revealed somatostatin and synaptophysin, suggesting a somatostatinoma. Twenty\u2010three reported cases of pancreatic somatostatinoma are reviewed and their clinical features discussed. The role of immunohistochemical studies in the diagnosis of somatostatinoma is described.<\/jats:p>","DOI":"10.1002\/jso.2930430414","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:47:14Z","timestamp":1171972034000},"page":"259-265","source":"Crossref","is-referenced-by-count":51,"title":["Pancreatic somatostatinoma: A case report and review of the literature"],"prefix":"10.1002","volume":"43","author":[{"given":"Kohki","family":"Konomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Chijiiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Katsuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92113-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197704282961703"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92578-8"},{"key":"e_1_2_1_5_2","first-page":"227","article-title":"Pancreatic hormon release in tumor\u2010associated hypersomatostatinaemia","volume":"15","author":"De Nutte N","year":"1978","journal-title":"Diabetologia"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-49-4-572"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-56-6-1236"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811302992213"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197908093010601"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.133.5.939"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1980.tb01382.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1980.tb01383.x"},{"key":"e_1_2_1_13_2","first-page":"30","article-title":"Pancreatic islet cell carcinoma producing gastrin, ACTH, alpha\u2010endorphin, somatostatin and calcitonin","volume":"74","author":"Asa SL","year":"1980","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_1_14_2","first-page":"309","article-title":"Glucose turnover and gluconeogenesis in a patient with somatostatinoma","volume":"89","author":"Lowry SF","year":"1981","journal-title":"Surgery"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-52-5-886"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(83)90309-4"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(83)90310-0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01487613"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.142.201"},{"key":"e_1_2_1_20_2","first-page":"525","article-title":"Pancreatic somatostatinoma with solitary liver metastasis: A successfuly resected case","volume":"2","author":"Kakumoto Y","year":"1984","journal-title":"Byori To Rinsho"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198410000-00046"},{"key":"e_1_2_1_22_2","first-page":"1285","article-title":"Somatostatinoma of the pancreas","volume":"35","author":"Shirouzu K","year":"1985","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427182"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<2273::AID-CNCR2820440641>3.0.CO;2-U"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-52-2-187"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930430414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930430414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T03:34:41Z","timestamp":1698032081000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930430414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4]]}},"alternative-id":["10.1002\/jso.2930430414"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930430414","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4]]}}}