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Our data indicate that all fibroadenomas were diploid, cystosarcoma phyllodes displayed diploid and aneuploid DNA content irrespective of their histological categorization, and that stromal sarcomas were all aneuploid and clinically aggressive. Diploid cystosarcoma phyllodes were biologically indolent, whereas most of the aneuploid neoplasms killed their hosts (<jats:italic>P<\/jats:italic> = 0.03). The present study indicates that a DNA content abnormality is a reliable marker of malignancy in these neoplasms, and it may identify subsets of patients with variable biologic courses within the histopathologic spectrum of cystosarcoma phyllodes.<\/jats:p>","DOI":"10.1002\/jso.2930440306","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:58:15Z","timestamp":1171972695000},"page":"151-156","source":"Crossref","is-referenced-by-count":10,"title":["Stromal neoplasms of the breast: A comparative flow cytometric study"],"prefix":"10.1002","volume":"44","author":[{"given":"Adel K.","family":"El\u2010Naggar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Mackay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour","family":"Sneige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Batsakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196203\/04)15:2<418::AID-CNCR2820150226>3.0.CO;2-V"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196510)18:10<1233::AID-CNCR2820181004>3.0.CO;2-M"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196807)22:1<22::AID-CNCR2820220105>3.0.CO;2-R"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1577::AID-CNCR2820400430>3.0.CO;2-D"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198504000-00020"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196712)20:12<2090::AID-CNCR2820201206>3.0.CO;2-L"},{"key":"e_1_2_1_8_2","first-page":"33","article-title":"Cystosarcoma phyllodes","volume":"120","author":"McDivitt RW","year":"1967","journal-title":"John Hopkins Medical Journal"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90236-2"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/70.2.211"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861115)58:10<2282::AID-CNCR2820581021>3.0.CO;2-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(87)90601-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(84)90119-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(85)80140-0"},{"key":"e_1_2_1_15_2","first-page":"3982","article-title":"Flow cytometry in clinical cancer research","volume":"43","author":"Barlogie B","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90017-6"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851015)56:8<2025::AID-CNCR2820560823>3.0.CO;2-C"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800721018"},{"key":"e_1_2_1_19_2","first-page":"2198","article-title":"Prognostic significance of nuclear DNA content in serous ovarian tumors","volume":"44","author":"Erhardt","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_20_2","first-page":"511","article-title":"Gastrointestinal stromal tumors: DNA flow cytometric study of 58 patients with at least five years of follow\u2010up","volume":"2","author":"Ei\u2010Naggar AK","year":"1989","journal-title":"Modern Pathol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890315)63:6<1161::AID-CNCR2820630620>3.0.CO;2-N"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.10.1690"},{"key":"e_1_2_1_23_2","first-page":"752","article-title":"Histopathological and clinical correlations of cystosarcoma phyllodes","volume":"112","author":"Murad TM","year":"1988","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/93.4.480"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891001)64:7<1486::AID-CNCR2820640721>3.0.CO;2-7"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/31.11.6619538"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1179\/his.1987.10.2.109"},{"key":"e_1_2_1_28_2","first-page":"333","article-title":"Determination of ploidy and proliferative characteristics of human solid tumors by pulse cytophotometry","volume":"38","author":"Barlogie B","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_29_2","first-page":"227","article-title":"Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. 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