{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:53:09Z","timestamp":1778845989089,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":5831,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent investigations suggest that adjuvant hyperthermia enhances the response of human malignant melanoma to ionizing radiation. A study was undertaken to explore the effect of radiation and hyperthermia on the responsiveness of melanoma following active immunization with lethally irradiated B16 melanoma cells in C57 BL 6 mice. Two groups of mice were treated: group 1 received immunotherapy on days 2\u20135 following tumor innoculation, and group 2 received immunotherapy on days 15\u201318 following tumor innoculation. The mice in each group were subsequently randomized into one of three subgroups: 1) no further treatment; 2) radiation therapy alone (6 Gy in a single fraction); 3) radiation therapy and regional hyperthermia (43\u00b0C \u00d7 1 hour). Tumor sizes were measured regularly, and between day 52 and 63 the animals were sacrificed and the lungs sectioned for counting of metastatic tumors. Results from this study show that the immunomodulated B16 murine melanoma is responsive to radiation therapy alone and that this responsiveness is enhanced by the addition of adjuvant regional hyperthermia. There did not appear to be any significant effect of radiation therapy or radiation therapy plus hyperthermia on the development of lung metastases in this tumor model system.<\/jats:p>","DOI":"10.1002\/jso.2930440413","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T11:57:21Z","timestamp":1171972641000},"page":"256-259","source":"Crossref","is-referenced-by-count":4,"title":["Effects of hyperthermia and irradiation on the growth of mouse melanoma tumors following immunotherapy"],"prefix":"10.1002","volume":"44","author":[{"given":"Daniel M.","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaddeus V.","family":"Samulski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Vervaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward C.","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Oleson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilliard","family":"Seigler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930120111"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(89)90017-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12680862"},{"key":"e_1_2_1_5_1","volume-title":"Practical Nonparametric Statistics","author":"Conover WJ","year":"1950"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656738809016491"},{"key":"e_1_2_1_7_1","first-page":"339","article-title":"Radiofrequency hyperthermiafor clinical cancer therapy","volume":"61","author":"Kim JH","year":"1982","journal-title":"NCI Monog"},{"key":"e_1_2_1_8_1","unstructured":"KolstergaardJ BartaM TomasovicSP(1989): Hyperthermic modulation of TNF\u2010dependent monocyte\/macrophage tumor cytotoxicity in vitro.J Biol Response Modifiers (in press)."},{"key":"e_1_2_1_9_1","first-page":"207","article-title":"The current condition and prognosis of tumor immunotherapy: A second opinion","volume":"68","author":"Mastrangelo MJ","year":"1984","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_10_1","first-page":"239","article-title":"Regional lymph node and pulmonary metastases after local hyperthermia of melanomas in C57BL\/6 mice","volume":"13","author":"Nathanson SD","year":"1987","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0147-0272(83)80004-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90378-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656738709140422"},{"key":"e_1_2_1_14_1","first-page":"506","volume-title":"Textbook of Surgery: The Biological Basis of Modern Surgical Practice","author":"Seigler HF","year":"1986"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197909000-00012"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(82)90074-8"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","unstructured":"TomasovicSP BartaM KlostergaardJ(1989): Temporal dependence of hyperthermic augmentation of macrophage\u2010TNF production and tumor cell\u2010TNF sensitization.Int J Hyperthermia(in press).","DOI":"10.3109\/02656738909140486"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-52-617-417"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930440413","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930440413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T14:33:05Z","timestamp":1697985185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930440413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,8]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,8]]}},"alternative-id":["10.1002\/jso.2930440413"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930440413","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,8]]}}}