{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:17:23Z","timestamp":1773155843808,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":5314,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1992,1]]},"abstract":"Abstract<\/jats:title>In a prospective study, 14 patients with primary non\u2010oat cell lung carcinoma were treated with intraoperative Iodine125<\/jats:sup> (I125<\/jats:sup>) implantation of the lung tumor via lateral thoracotomy or median sternotomy. Staging mediastinal node dissection was performed in each case. Patients were selected when wedge or segmental resections were not technically feasible, such that lobectomy or completion pneumonectomy would have been required or pulmonary function studies were poor. Doses ranged from 8,000 cGy at the periphery to 20,000 cGy at the center. With a minimum 12 month follow\u2010up, mean and median survivals were 16.7 and 15.1 months, respectively. Local control was achieved in 10 of 14 patients (71%) with all local failures occurring in pathologic stage III patients. When separated according to tumor size, local control was obtained in six of seven tumors of less than 3 cm and four of five tumors of 3\u20105 cm. Both cases with masses greater than 5 cm failed locally. There was one operative mortality and two postoperative complications. All other patients were discharged within one week of surgery. There was no radiation pneumonitis. I125<\/jats:sup> lung brachytherapy is an excellent alternative treatment for T1 and T2 tumors when medical conditions preclude curative resection.<\/jats:p>","DOI":"10.1002\/jso.2930490107","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T12:59:05Z","timestamp":1171976345000},"page":"25-28","source":"Crossref","is-referenced-by-count":23,"title":["Iodine125<\/sup> interstitial brachytherapy in the treatment of carcinoma of the lung"],"prefix":"10.1002","volume":"49","author":[{"given":"Erik H.","family":"Fleischman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Robert","family":"Kagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar E.","family":"Streeter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Tyrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron","family":"Wollin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Leagre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"246","article-title":"Selecting patients with lung cancer for surgical therapy","volume":"15","author":"Johnston MR","year":"1988","journal-title":"Semin Oncol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.5.968"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198309000-00015"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)63785-X"},{"key":"e_1_2_1_6_2","first-page":"1","article-title":"Selection of patients for surgery of bronchogenic carcinoma","volume":"38","author":"Paulson DL","year":"1973","journal-title":"Ann Surg"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)63157-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90348-3"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800215)45:4<698::AID-CNCR2820450414>3.0.CO;2-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1200\/JCO.1990.8.9.1543","article-title":"A randomized phase I\/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: report of radiation therapy oncology group 83\u201011","volume":"8","year":"1990","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90230-1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(83)90174-8"},{"key":"e_1_2_1_13_2","first-page":"650","volume-title":"Principles and Practices of Radiation Oncology","author":"Emami B","year":"1987"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930490107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930490107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T19:50:33Z","timestamp":1698090633000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930490107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/jso.2930490107"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930490107","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}