{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:17:03Z","timestamp":1763662623750},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":5161,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Management of melanoma of the external ear is controversial. Thirty\u2010one patients treated for this disease were identified at our institution between January 1, 1974 and December 31, 1989. Follow\u2010up was an average of 7.12 years (range 1\u201315). Local therapy performed included 16 wedge resections, 3 split thickness skin grafts after excision to the perichondrium, 10 partial and 2 total amputations. There were two local recurrences, four metachronous cervical metastases, and four distant metastases. Three elective and five therapeutic neck dissections were performed. Survivors at 1, 5, and 10 years were 93, 77, and 47%, respectively. There was no relationship between DNA ploidy, local surgical therapy, and eventual recurrence. Clinical stage and tumor thickness demonstrated a statistically significant correlation with likelihood of recurrence (<jats:italic>P<\/jats:italic> = .02 and .05). There is no evidence that melanoma of the ear has a poorer prognosis or different prognostic factors than melanoma at other cutaneous sites. In selected cases, local disease can be controlled by excision and skin graft rather than the more aggressive current procedures. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jso.2930500211","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T12:39:17Z","timestamp":1171975157000},"page":"110-114","source":"Crossref","is-referenced-by-count":42,"title":["Melanoma of the external ear"],"prefix":"10.1002","volume":"50","author":[{"given":"David J.","family":"Cole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Mackay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce F.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Wooden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"John J.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90203-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880815)62:4<831::AID-CNCR2820620432>3.0.CO;2-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90325-1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00000658-198011000-00008","article-title":"Selective surgical management of cutaneous melanoma of the head and neck","volume":"192","author":"Roses DF","year":"1980","journal-title":"Ann Surg"},{"key":"e_1_2_1_6_2","first-page":"20A","article-title":"Semiautomation of preparation of fixed paraffin embedded tissue for DNA analysis","volume":"62","author":"Cohen C","year":"1990","journal-title":"Lab Invest"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/31.11.6619538"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1288\/00005537-198908000-00010","article-title":"Cutaneous malignant melanoma of the head and neck","volume":"99","author":"Fischer SR","year":"1989","journal-title":"Laryngoscope"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(70)80001-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198412000-00017"},{"key":"e_1_2_1_12_2","first-page":"257","article-title":"Flow cytometry and prognostic implications in patients with solid tumors","volume":"171","author":"Williams NN","year":"1990","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198804000-00014"},{"key":"e_1_2_1_14_2","first-page":"705","article-title":"The histogenesis and biologic behavior of primary human malignant melanoma of the skin","volume":"29","author":"Clark WH","year":"1969","journal-title":"Cancer Res"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930500211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930500211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T20:16:44Z","timestamp":1698092204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930500211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["10.1002\/jso.2930500211"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930500211","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}