{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:33:31Z","timestamp":1758706411029},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":5132,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Out of 36 consecutive patients who underwent a pancreatoduodenectomy for carcinoma of the ampulla of Vater, eight patients (long\u2010term survivors) survived more than 5 years after surgery, while eight other patients (short\u2010term survivors) survived less than 12 months after intervention. Both the eight long\u2010term survivors and eight short\u2010term survivors were compared clinicopathologically. The long\u2010term survivors did have some preferable factors such as a high value of peripheral lymphocytes, a low concentration of carcinoembryonic antigen, a small protruding tumor, a shallow depth of invasion, a well\u2010differentiated histopathologic type, an infrequent venous invasion, and no perineural infiltration. However, these differences were not significant. A multivariate regression analysis regarding the 18 prognostic variables showed that both perineural invasion and the grade of histopathologic differentiation were significant parameters. Out of the eight long\u2010term survivors, three patients lived more than 10 years while another died from ampullary carcinoma 74 months after surgery. Pancreatoduodenectomy not only produces long\u2010term survivors but can also effect a complete cure in patients with ampullary carcinoma. A long clinical follow\u2010up of more than 5 years after surgical intervention is thus warranted. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jso.2930500314","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T12:38:57Z","timestamp":1171975137000},"page":"195-200","source":"Crossref","is-referenced-by-count":21,"title":["Long\u2010 and short\u2010term survivors after pancreatoduodenectomy for ampullary carcinoma"],"prefix":"10.1002","volume":"50","author":[{"given":"Koji","family":"Yamaguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Nishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870201)59:3<506::AID-CNCR2820590326>3.0.CO;2-#"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198910000-00015"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930470303"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930450314"},{"key":"e_1_2_1_6_2","first-page":"994","article-title":"Non\u2010icteric ampullary carcinoma with a favorable prognosis","volume":"85","author":"Yamaguchi K","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_1_7_2","first-page":"14","article-title":"Carcinoma of the pancreas. 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