{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:14:00Z","timestamp":1789755240614,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":4978,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidemiologic studies have suggested that vagotomy increases subsequent colorectal cancer risk. This hypothesis was investigated in the rat 1,2 dimethylhydrazine (DMH) colorectal carcinogenesis model. Eighty\u2010five rats were divided into four groups having either truncal vagotomy and Heineke\u2010Mickulicz pyloroplasty, pyloroplasty alone, laparotomy alone, and anesthesia alone. After recovery from the procedures, colon tumors were induced with five injections of DMH. Results of carcinogenesis show a trend towards increased incidence and yield of colorectal and duodenal tumors after vagotomy, though this was not statistically significant, perhaps because the high postoperative mortality from vagotomy diminished the power of the Study. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jso.2930510416","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T13:05:36Z","timestamp":1171976736000},"page":"281-286","source":"Crossref","is-referenced-by-count":20,"title":["The effect of vagotomy and pyloroplasty on colorectal tumor induction in the rat"],"prefix":"10.1002","volume":"51","author":[{"given":"Richard L.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Briley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio P.","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hercand","family":"Abcarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800720811"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198208263070902"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6427.1335"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800771004"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-85930-4_1","volume-title":"Colorectal Cancer: From Pathology to Prevention?","author":"Stemmermann G","year":"1989"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740709"},{"key":"e_1_2_1_8_2","first-page":"337","article-title":"The long\u2010term prognosis of patients gastrectomized for benign gastroduodenal diseases","volume":"78","author":"Asano A","year":"1987","journal-title":"Jpn J Cancer Res"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.8.924"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.148.2.405"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199012000-00010"},{"key":"e_1_2_1_12_2","first-page":"87","article-title":"Esophageal cancer developed after gastrectomy","volume":"99","author":"Maeta M","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/13.3.299"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(69)90050-X"},{"key":"e_1_2_1_15_2","first-page":"399","volume-title":"Surgery of the Stomach and Duodenum","author":"Cox AG","year":"1977"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(87)90195-4"},{"key":"e_1_2_1_17_2","first-page":"310","article-title":"Validation of tests of completeness of vagotomy in rats","volume":"9","author":"Sylvestre JL","year":"1983","journal-title":"J. Auton Nerv Syst"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1949.01240040215004"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(83)90146-7"},{"key":"e_1_2_1_20_2","first-page":"27","article-title":"Metabolic problems after gastric surgery","volume":"75","author":"Harju E","year":"1990","journal-title":"Int surg"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(85)90125-9"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770719"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.aje.a114366","article-title":"Total energy intake: Implications for epidemiologic analyses","volume":"124","author":"Willett WC","year":"1987","journal-title":"Am J Epidimiol"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635588709513929"},{"key":"e_1_2_1_25_2","first-page":"1226","article-title":"Effect of restricted caloric intake on azoxymethane\u2010induced colon tumor incidence in male F344 rats","volume":"47","author":"Reddy B","year":"1987","journal-title":"Cancer Res"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930510416","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930510416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:06:12Z","timestamp":1698051972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930510416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,12]]}},"alternative-id":["10.1002\/jso.2930510416"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930510416","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12]]}}}