{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:54:12Z","timestamp":1760079252006},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4767,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since 1983, 77 patients have had limb salvage surgery for locally aggressive or malignant bone tumor of the limbs or pelvis. Twenty\u2010nine patients had locally aggressive, lesions with giant cell tumors the most prevalent, and 48 patients had malignant lesions, of which osteosarcomas predominated. Resection with a wide margin could be achieved in most of the patients. A mobile joint reconstruction was performed in 57 patients and an arthrodesis in 14 patients. At follow\u2010up, 14 patients have died of disease, 7 patients have survived with disease, and 56 patients (73%) have survived without disease. Local recurrences were encountered in 4 patients (5%). The overall functional results were classified as excellent in 11 patients, good in 45 patients, and fair in 9 patients. Twelve patients had poor results because of failure of the reconstruction or amputation due to complications. Twenty\u2010seven complications were encountered, among which infection was the most serious. Careful selection of patients and consideration of procedure chosen to reconstruct the defect are important for a successful outcome. This decision is based on a number of factors related to the tumor and the patient. Presently, major neurovascular involvement, displaced pathological fracture, inappropriate biopsy incision, extreme youth of the patient, and infection were considered to be contraindications to resection in our institution. Although various procedures promise functional restoration, the reconstructive procedure should be individualized and designed to meet the needs of the patient. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jso.2930530305","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T13:00:24Z","timestamp":1171976424000},"page":"154-160","source":"Crossref","is-referenced-by-count":9,"title":["Limb salvage surgery for locally aggressive and malignant bone tumors"],"prefix":"10.1002","volume":"53","author":[{"given":"Lih\u2010Yuann","family":"Shih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tain\u2010Shung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai\u2010Hee","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655667"},{"key":"e_1_2_1_3_2","first-page":"335","volume-title":"Tumor Prostheses for Bone and Joint Reconstruction: The Design and Application","author":"Chao EYS","year":"1983"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.42"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-196749010-00008"},{"key":"e_1_2_1_6_2","first-page":"249","article-title":"Giant cell tumors of bone: A study of 209 cases with long\u2010term follow\u2010up in 130","volume":"1","author":"Campanacci M","year":"1975","journal-title":"Ital J Orthop Traumatol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00003086-198011000-00013","article-title":"A system for the surgical staging of musculoskeletal sarcoma","volume":"153","author":"Enneking WF","year":"1980","journal-title":"Clin Orthop"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1302\/0301-620X.64B2.6978340","article-title":"Improved three\u2010year disease\u2010free survival in osteogenic sarcoma: Efficacy of adjuvant chemotherapy","volume":"64","author":"Bleyer WA","year":"1982","journal-title":"J Bone Jt Surg"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00003086-199109000-00008","article-title":"A review of 13\u2010years experience of osteosarcoma","volume":"270","author":"Carter SR","year":"1991","journal-title":"Clin Orthop"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920201)69:3<698::AID-CNCR2820690317>3.0.CO;2-G"},{"key":"e_1_2_1_11_2","first-page":"95","article-title":"Osteogenic sarcoma: State of the art with high\u2010dose meth\u2010otrexate treatment","volume":"120","author":"Jaffe N","year":"1976","journal-title":"Clin Orthop"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00003086-199109000-00012","article-title":"Current management, local management, and survival statistics of high grade osteosarcoma. Experience in Japan","volume":"270","author":"Ogihara Y","year":"1991","journal-title":"Clin Orthop"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820315)49:6<1221::AID-CNCR2820490625>3.0.CO;2-E"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/00003086-199101000-00009","article-title":"Limb reconstruction with vascularized fibular grafts after bone tumor resection","volume":"262","author":"Brown KL","year":"1991","journal-title":"Clin Orthop"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00003086-199106000-00007","article-title":"Resection of malignant bone tumors about the shoulder","volume":"267","author":"Frassica FJ","year":"1991","journal-title":"Clin Orthop"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.2106\/00004623-199173020-00017","article-title":"Prosthetic arthro\u2010plasty of the knee after resection of a sarcoma in the proximal end of the tibia","volume":"73","author":"Horowitz SM","year":"1991","journal-title":"J Bone Jt Surg"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0030-5898(20)31634-5","article-title":"Mobile knee reconstruction after resection of malignant tumors of the distal femur","volume":"22","author":"Kneisl JS","year":"1991","journal-title":"Orthop Clin North Am"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00003086-198705000-00032","article-title":"Fibular reconstruction for giant cell tumor of the distal radius","volume":"218","author":"Lackman RD","year":"1987","journal-title":"Clin Orthop"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00003086-198902000-00027","article-title":"Limb\u2010sparing surgery for high grade malignant tumors of the proximal tibia","volume":"239","author":"Malawer MM","year":"1989","journal-title":"Clin Orthop"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2106\/00004623-197961060-00014","article-title":"Prosthetic replacement of the knee and a large segment of the femur or tibia","volume":"61","author":"Sim FH","year":"1979","journal-title":"J Bone Jt Surg"},{"key":"e_1_2_1_21_2","first-page":"188","article-title":"Reconstruction of musculoskeletal defects about the knee for tumor","volume":"221","author":"Sim FH","year":"1987","journal-title":"Clin Orthop"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00003086-199109000-00034","article-title":"Limb salvage for osteosarcoma in the 1980s","volume":"270","author":"Simon MA","year":"1991","journal-title":"Clin Orthop"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1302\/0301-620X.70B3.3163694","article-title":"Limb conservation in primary bone tumors by resection, extracorporeal irradiation and reimplantation","volume":"70","author":"Uyttendaele D","year":"1988","journal-title":"J Bone Jt Surg"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678809149397"},{"key":"e_1_2_1_25_2","first-page":"626","volume-title":"Limb Salvage in Musculoskeletal Oncology","author":"Enneking WF","year":"1987"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072100-00008"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900401)65:7<1509::AID-CNCR2820650710>3.0.CO;2-I"},{"key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/00003086-199011000-00040","article-title":"Complications associated with limb salvage for extremity sarcomas and their management","volume":"260","author":"Quill G","year":"1990","journal-title":"Clin Orthop"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjso.2930530305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.2930530305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T18:17:49Z","timestamp":1698257869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.2930530305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1002\/jso.2930530305"],"URL":"https:\/\/doi.org\/10.1002\/jso.2930530305","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}