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A multivariate analysis showed that K\u2010ras mutation correlated with vascular invasion (<jats:italic>P<\/jats:italic>&lt; 0.01) and hematogenous metastasis (<jats:italic>P<\/jats:italic>&lt; 0.01). With regard to survival time, multivariate analyses using the Cox proportional hazard model suggested that status of lymph node metastasis (<jats:italic>P<\/jats:italic>&lt;0.01, relative risk [rr]=7.27), TNM stage (<jats:italic>P<\/jats:italic>&lt; 0.05, rr=5.37), lymphatic invasion (<jats:italic>P<\/jats:italic>&lt; 0.05, rr=4.48), and K\u2010ras mutation (<jats:italic>P<\/jats:italic>&lt; 0.06, rr=3.69) are the most independent prognostic factors. We compared the prognostic value of the molecular assays and standard TNM prognostic factors by multivariate analysts. \u00a9 1994 Wiley\u2010Liss, inc.<\/jats:p>","DOI":"10.1002\/jso.2930570115","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T13:42:38Z","timestamp":1171978958000},"page":"57-64","source":"Crossref","is-referenced-by-count":52,"title":["Prognostic factors of colorectal cancer: K\u2010ras mutation, overexpression of the p53 protein, and cell proliferative activity"],"prefix":"10.1002","volume":"57","author":[{"given":"Matsuhei","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Omura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoh","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Oda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809013190901"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040115"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199008303230902"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V75.5.1163.1163"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1991.tb02710.x"},{"key":"e_1_2_1_7_2","first-page":"5494","article-title":"Retrospective analysis of the prognostic significance of DNA content and proliferative activity in large bowel carcinomas","volume":"47","author":"Schutte B","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_2","first-page":"32","article-title":"Japanese Research Society for Cancer of Colon and Rectum: The general rules for clinical and pathological studies on cancer of colon, rectum and anus","volume":"5","year":"1985","journal-title":"Jpn J Surg"},{"key":"e_1_2_1_9_2","volume-title":"TNM Classification of Malignant Tumors","author":"Hermanek P","year":"1987"},{"key":"e_1_2_1_10_2","first-page":"50","article-title":"Japanese Research Society for Gastric Cancer: The general rules for the gastric cancer study","volume":"11","year":"1985","journal-title":"Jpn J Surg"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(87)52018-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2999980"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(86)90335-5"},{"key":"e_1_2_1_14_2","first-page":"309","article-title":"Monoclonal antibodies to human intermediate filament proteins. 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