{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:05:15Z","timestamp":1775469915235,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Melanoma is one of the fastest\u2010growing cancers in the United States, with nearly 100% 5\u2010year survival for early\u2010stage disease compared to 35% for late\u2010stage disease. Regional studies suggest that areas with increased early\u2010stage melanoma diagnoses may not experience a reduction in late\u2010stage cases, raising questions about the effectiveness of early detection. We hypothesize that higher socioeconomic status (SES) will correlate with increased early\u2010stage melanoma without a decrease in late\u2010stage disease, with geographic variation across US regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study used SEER data to analyze 829\u2009391 non\u2010Hispanic White patients diagnosed with melanoma between 2004 and 2021, including 725\u2009077 with early\u2010stage (in situ\/localized) and 104\u2009314 with late\u2010stage (regional\/distant) disease. Regression models evaluated associations between county\u2010level stage\u2010specific melanoma incidence and population characteristics, including SES, ultraviolet exposure, agricultural employment, and rural\u2010urban status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher SES counties had higher early\u2010stage melanoma incidence without a reduction in late\u2010stage incidence. Counties in the West and South had increased odds of early\u2010stage melanoma, while rural counties exhibited lower melanoma incidence across stages. Agricultural employment and ultraviolet exposure were not consistently associated with melanoma incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings suggest early\u2010 and late\u2010stage melanoma may represent distinct diseases. Screening may aid in early detection, but its impact on reducing late\u2010stage disease and mortality remains uncertain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.70036","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T12:41:15Z","timestamp":1752151275000},"page":"465-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Socioeconomic Influences on Melanoma Incidence Patterns by Stage in the US"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5821-1159","authenticated-orcid":false,"given":"Trisha","family":"Lal","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology University Hospitals Cleveland Medical Center Cleveland Ohio"},{"name":"School of Medicine Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weichuan","family":"Dong","sequence":"additional","affiliation":[{"name":"Case Comprehensive Cancer Center, School of Medicine Case Western Reserve University Cleveland Ohio"},{"name":"Department of Population and Quantitative Health Sciences, School of Medicine Case Western Reserve University Cleveland Ohio"},{"name":"Center for Cardiovascular Computational and Precision Health (C3PH), Department of Cardiology Houston Methodist Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siran M.","family":"Koroukian","sequence":"additional","affiliation":[{"name":"School of Medicine Case Western Reserve University Cleveland Ohio"},{"name":"Case Comprehensive Cancer Center, School of Medicine Case Western Reserve University Cleveland Ohio"},{"name":"Department of Population and Quantitative Health Sciences, School of Medicine Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie N.","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology University Hospitals Cleveland Medical Center Cleveland Ohio"},{"name":"School of Medicine Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke D.","family":"Rothermel","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology University Hospitals Cleveland Medical Center Cleveland Ohio"},{"name":"School of Medicine Case Western Reserve University Cleveland Ohio"},{"name":"Case Comprehensive Cancer Center, School of Medicine Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard S.","family":"Hoehn","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology University Hospitals Cleveland Medical Center Cleveland Ohio"},{"name":"School of Medicine Case Western Reserve University Cleveland Ohio"},{"name":"Case Comprehensive Cancer Center, School of Medicine Case Western Reserve University Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci9040063"},{"key":"e_1_2_8_3_1","unstructured":"\u201cMelanoma of the Skin \u2010 Cancer Stat Facts \u201d SEER accessed September 25 2024 https:\/\/seer.cancer.gov\/statfacts\/html\/melan.html."},{"issue":"6","key":"e_1_2_8_4_1","first-page":"1005","article-title":"Melanoma: Epidemiology, Risk Factors, Pathogenesis, Diagnosis and Classification","volume":"28","author":"Rastrelli M.","year":"2014","journal-title":"In Vivo (Athens, 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