{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:12:45Z","timestamp":1758672765650,"version":"3.44.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The vascular groove (VG) is no longer considered a resection margin but rather a surface of involvement. The clinical significance of an isolated VG+ remains debated. Therefore, this study evaluates the impact of isolated VG+, with or without vein resection, on overall survival (OS) and disease\u2010free survival (DFS) following pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 247 patients (2006\u20132019) was conducted. Patients were categorized into three groups: R0 resection (tumor\u2009&gt;\u20091\u2009mm from all margins, <jats:italic>n<\/jats:italic>\u2009=\u2009168), VG+ without vein invasion (+VGnoVI, <jats:italic>n<\/jats:italic>\u2009=\u200966), and positive vein involvement with direct tumor invasion into the vein wall (+VGwithVI) (<jats:italic>n<\/jats:italic>\u2009=\u200913). Kaplan\u2010Meier estimates assessed OS and DFS, while multivariable analyses identified recurrence and survival predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>+VGnoVI group showed higher rates of local recurrence (OR 2.68, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) compared to the R0 group. However, no significant differences were observed in DFS (R0: 17 months; +VGnoVI: 18 months; +VGwithVI: 21 months, <jats:italic>p<\/jats:italic>\u2009=\u20090.68) or OS (R0: 27 months; +VGnoVI: 29 months; +VGwithVI: 30 months, <jats:italic>p<\/jats:italic>\u2009=\u20090.98) across groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A positive vascular groove, whether isolated or associated with vein invasion, does not compromise OS or DFS compared to R0 resections.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jso.70052","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:24Z","timestamp":1753879164000},"page":"684-694","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implications of an Isolated Positive Vascular Groove After Whipple for Pancreatic Adenocarcinoma: A Single Institution, Retrospective Analysis"],"prefix":"10.1002","volume":"132","author":[{"given":"Callie A.","family":"Hlavin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine University of Pittsburgh School of Medicine Pittsburgh PA USA"},{"name":"Division of GI Surgical Oncology, UPMC Pancreatic Cancer Center University of Pittsburgh Medical Center, UPMC Cancer Pavilion Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiaan","family":"Ceuppens","sequence":"additional","affiliation":[{"name":"Division of GI Surgical Oncology, UPMC Pancreatic Cancer Center University of Pittsburgh Medical Center, UPMC Cancer Pavilion Pittsburgh PA USA"},{"name":"Department of Surgery Erasmus Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Tirukkovalur","sequence":"additional","affiliation":[{"name":"Division of GI Surgical Oncology, UPMC Pancreatic Cancer Center University of Pittsburgh Medical Center, UPMC Cancer Pavilion Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiage","family":"Qian","sequence":"additional","affiliation":[{"name":"Division of GI Surgical Oncology, UPMC Pancreatic Cancer Center University of Pittsburgh Medical Center, UPMC Cancer Pavilion Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aatur D.","family":"Singhi","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Pathology New York University Grossman School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Nassour","sequence":"additional","affiliation":[{"name":"Division of GI Surgical Oncology, UPMC Pancreatic Cancer Center University of Pittsburgh Medical Center, UPMC Cancer Pavilion Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of GI Surgical Oncology, UPMC Pancreatic Cancer Center University of Pittsburgh Medical Center, UPMC Cancer Pavilion Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer H.","family":"Zureikat","sequence":"additional","affiliation":[{"name":"Division of GI Surgical Oncology, UPMC Pancreatic Cancer Center University of Pittsburgh Medical Center, UPMC Cancer Pavilion Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-1711","authenticated-orcid":false,"given":"Alessandro","family":"Paniccia","sequence":"additional","affiliation":[{"name":"Division of GI Surgical Oncology, UPMC Pancreatic Cancer Center University of Pittsburgh Medical Center, UPMC Cancer Pavilion Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21551"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"e_1_2_9_4_1","unstructured":"American Cancer Society Cancer Facts and Figures 2022 2022."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/BJS.4484"},{"key":"e_1_2_9_6_1","unstructured":"L. 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