{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T22:25:44Z","timestamp":1771280744620,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemicondylar fresh frozen allografts address partial knee defects while preserving native anatomy and bone stock. This study evaluated long\u2010term survival, failure modes, and functional outcomes following hemicondylar reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of hemicondylar fresh frozen allograft reconstructions. Allograft failure was assessed using the Henderson classification and osteoarthritis via Kellgren\u2013Lawrence classification. Functional outcomes were evaluated using MSTS scores and patient\u2010reported measures, with radiographic evaluation performed preoperatively and at 1, 2, 5, and 10 years postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 17 patients (13 femoral, 4 tibial allografts) with a median age of 29 years and a median follow\u2010up of 16.9 years were included. Four patients (24%) experienced allograft failure, including two structural failures, one infection, and one soft\u2010tissue failure. Overall allograft survival was 87.5% at 1 year, 80.8% at 2 years, and 74% at 5\u201320 years, with a median MSTS score of 21\/30. While all patients developed progressive osteoarthritis, only six required total knee arthroplasty for symptomatic arthritis rather than allograft failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hemicondylar allografts demonstrate acceptable long\u2010term survival and functional outcomes, with progressive osteoarthritis\/chondrolysis representing expected evolution rather than treatment failure. Structural collapse remains the predominant failure mechanism requiring removal. These findings support hemicondylar allografts as viable reconstructive options for selected patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>Level IV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70081","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T13:41:58Z","timestamp":1757425318000},"page":"1122-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Functional Outcomes and Modes of Failure of Fresh Frozen Hemicondylar Allografts: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"132","author":[{"given":"Arturo M.","family":"De Pena","sequence":"first","affiliation":[{"name":"Orthopedic Oncology Service, Department of Orthopedic Surgery Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3352-6362","authenticated-orcid":false,"given":"Marcos R.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Orthopedic Oncology Service, Department of Orthopedic Surgery Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Orthopedic Oncology Service, Department of Orthopedic Surgery Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-9004","authenticated-orcid":false,"given":"Santiago A.","family":"Lozano\u2010Calderon","sequence":"additional","affiliation":[{"name":"Orthopedic Oncology Service, Department of Orthopedic Surgery Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.873323"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.118603"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2008.07.011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2014.10.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2536-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08710-x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-04037-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.07.043"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200710000-00006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-012-2455-8"},{"issue":"11","key":"e_1_2_10_12_1","first-page":"1436","article-title":"Classification of Failure of Limb Salvage After Reconstructive Surgery for Bone Tumours: A Modified System Including Biological and Expandable Reconstructions","volume":"96","author":"Henderson E. R.","year":"2014","journal-title":"Bone & Joint Journal"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31100465"},{"issue":"4","key":"e_1_2_10_14_1","first-page":"522","article-title":"Is There Still a Role for Osteoarticular Allograft Reconstruction in Musculoskeletal Tumour Surgery? A Long\u2010Term Follow\u2010Up Study of 38 Patients and Systematic Review of the Literature","volume":"99","author":"Bus M. P. A.","year":"2017","journal-title":"Bone & Joint Journal"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2014.049"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2017.10.003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B6.37417"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1601414"},{"issue":"2","key":"e_1_2_10_19_1","first-page":"206","article-title":"Unicondylar Osteoarticular Allografts of the Knee: Surgical Technique","volume":"90","author":"Muscolo D. L.","year":"2008","journal-title":"Journal of Bone and Joint Surgery"},{"issue":"10","key":"e_1_2_10_20_1","first-page":"1174","article-title":"A Comparison of Osteoarticular Allografts and Allograft\u2010Prosthesis Composites for Reconstruction of the Distal Femur After Resection of a Bone Tumour in Childhood: A Retrospective Study","volume":"104","author":"Jamshidi K.","year":"2022","journal-title":"Bone & Joint Journal"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-007-0055-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2017.07.018"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001853"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2012.01.020"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.70081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T21:42:49Z","timestamp":1771278169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.70081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jso.70081"],"URL":"https:\/\/doi.org\/10.1002\/jso.70081","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"2025-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}