{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:31:42Z","timestamp":1779910302699,"version":"3.53.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>CMTM4<\/jats:italic>\n                      (CKLF\u2010like MARVEL transmembrane domain containing 4), a member of chemokine\u2010like factor gene super\u2010family, has been identified as a potential tumor suppressor gene in several malignancies and is implicated in biological processes such as tumor cell proliferation, adhesion, and migration. However, the role of\n                      <jats:italic>CMTM4<\/jats:italic>\n                      in colorectal cancer remains unspecified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The expression level of\n                      <jats:italic>CMTM4<\/jats:italic>\n                      in colorectal malignant tissues were analyzed, and correlations between\n                      <jats:italic>CMTM4<\/jats:italic>\n                      expression and clinicopathological features were analyzed in individuals with colorectal cancer. Bioinformatic analysis of\n                      <jats:italic>CMTM4<\/jats:italic>\n                      expression in colorectal cancer and adjacent normal tissues was conducted using Oncomine and GenomicScape. Correlation analyses between\n                      <jats:italic>CMTM4<\/jats:italic>\n                      and the genes\n                      <jats:italic>MYC<\/jats:italic>\n                      and\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      were conducted using The Cancer Genome Atlas (TCGA) data set. The relationship between\n                      <jats:italic>CMTM4<\/jats:italic>\n                      expression and overall survival in individuals with colorectal cancer was analyzed using TCGA and Gene Expression Omnibus datasets. Immunohistochemical images of CMTM4 protein expression were obtained from the Human Protein Atlas database.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>CMTM4<\/jats:italic>\n                      expression was significantly downregulated in colorectal cancer tissues compared to normal tissues. A positive correlation was observed between\n                      <jats:italic>CMTM4<\/jats:italic>\n                      and\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      expression, whereas a negative correlation was observed between\n                      <jats:italic>CMTM4<\/jats:italic>\n                      and\n                      <jats:italic>MYC<\/jats:italic>\n                      expression. Higher\n                      <jats:italic>CMTM4<\/jats:italic>\n                      expression levels were associated with improved survival time in individuals diagnosed with colorectal cancer, indicating its tumor\u2010suppressive role within the\n                      <jats:italic>CMTM<\/jats:italic>\n                      family.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>CMTM4<\/jats:italic>\n                      is often downregulated in colorectal cancer and exhibits tumor\u2010suppressive properties. These findings indicate that\n                      <jats:italic>CMTM4<\/jats:italic>\n                      may serve as a potential therapeutic target for colorectal cancer.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70089","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:00:18Z","timestamp":1758546018000},"page":"1243-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Downregulation of\n                    <i>CMTM4<\/i>\n                    and Its Tumor\u2010Suppressive Role in Colorectal Cancer: Insights From Expression and Survival Analyses"],"prefix":"10.1002","volume":"132","author":[{"given":"Guoquan","family":"Jin","sequence":"first","affiliation":[{"name":"Department of General Surgery The Fifth People's Hospital of Qinghai Province Xining 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