{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:05:10Z","timestamp":1793318710811,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The prognostic differences between subcutaneous leiomyosarcoma and dermal leiomyosarcoma are not well defined due to limited cohort sizes and insufficient follow\u2010up in prior studies. This study aimed to investigate the clinicopathological features of subcutaneous and dermal leiomyosarcoma and estimate their 10\u2010year rates of metastasis, local recurrence, and overall survival. Additionally, we propose standardized follow\u2010up recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients diagnosed with cutaneous leiomyosarcoma in Denmark from 1980 to 2022 were included. The prognosis was estimated using age\u2010 and sex\u2010standardized stratified cause\u2010specific Cox\u2010regression with all\u2010cause mortality as competing risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 196 patients with subcutaneous leiomyosarcoma and 465 with dermal leiomyosarcoma. The 10\u2010year local recurrence rate was similar in patients with subcutaneous leiomyosarcoma (15%) and dermal leiomyosarcoma (11%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.13). However, patients with subcutaneous leiomyosarcoma had a significantly higher 10\u2010year risk of metastasis (25%), primarily observed in grade 2 and 3 tumors, compared with dermal leiomyosarcoma (2.7%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, and a lower 10\u2010year\u2010overall survival (56% vs. 64%),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Grade 2 and 3 subcutaneous leiomyosarcoma should be classified as a high\u2010risk sarcoma with a substantial risk of metastasis and poor overall survival, necessitating follow\u2010up that includes both clinical examinations and PET\/CT or CT of the thorax for 5 years to detect both locoregional and distant metastases. Dermal leiomyosarcoma should be considered a low\u2010risk sarcoma due to its low risk of metastasis and moderate risk of local recurrence, suggesting that the follow\u2010up can focus on clinical examinations for 4 years as the 10\u2010year risk of local recurrence is &lt;\u20091% after this time point.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70095","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:18:11Z","timestamp":1758197891000},"page":"1076-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognosis and Follow\u2010Up Recommendations for Subcutaneous and Dermal Leiomyosarcoma: Local Recurrence, Metastasis, and Overall Survival in a Danish Nationwide Cohort of 661 Patients"],"prefix":"10.1002","volume":"132","author":[{"given":"Kiya","family":"Abebe","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery and Burns Treatment Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-8392","authenticated-orcid":false,"given":"Mathias","family":"\u00d8rholt","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burns Treatment Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik E. 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