{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:31:31Z","timestamp":1782304291611,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Neoadjuvant chemoimmunotherapy (NACI) for node\u2010positive breast cancer may induce immune cell activation in regional lymph nodes (LN), confounding post\u2010NACI imaging. Here we evaluated RECIST 1.1 criteria to predict post\u2010NACI pathologic LN status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied patients with biopsy\u2010proven cN+ non\u2010distant metastatic breast cancer receiving NACI operated on 03\/2020\u201309\/2024 with both pre\u2010 and post\u2010NACI cross\u2010sectional imaging. Per RECIST 1.1, LN short axis diameter (SAD) was measured in target (defined as SAD\u2009\u2265\u200915\u2009mm) and nontarget (SAD 10\u201314.9\u2009mm) LNs. Groups were compared using Fisher\u2032s exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      75 patients, median age 53 years, were studied: 61% cN1, 12% cN2, and 27% cN3. Baseline median number of imaging\u2010suspicious LN was 4 (IQR 2\u20105). Post\u2010NACI, 64% had a nodal pathologic complete response (pCR\/ypN0). 55% met RECIST 1.1 LN assessment criteria. 21 of 32 (66%) with an imaging CR (iCR) were ypN0, while 8 of 9 (89%) without an iCR were ypN0. Neither target (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.24) nor combined target\/nontarget LN iCR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.76) predicted ypN status. Nodal pCR rates were higher in those with \u2264\u20091 versus &gt;\u20091 suspicious LN post\u2010NACI (71%\n                      <jats:italic>vs.<\/jats:italic>\n                      42%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RECIST 1.1 criteria did not predict nodal pCR for NACI\u2010treated node\u2010positive breast cancer patients. Other post\u2010NACI imaging assessment strategies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70096","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:43:28Z","timestamp":1758703408000},"page":"1218-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does RECIST 1.1 Predict Nodal Response to Neoadjuvant Chemo\u2010Immunotherapy in Breast Cancer?"],"prefix":"10.1002","volume":"132","author":[{"given":"Matteo","family":"Redaelli","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Breast and Melanoma Surgical Oncology Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Steadman","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Breast and Melanoma Surgical Oncology Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya L.","family":"Hoskin","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4277-8692","authenticated-orcid":false,"given":"Tina J.","family":"Hieken","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Breast and Melanoma Surgical Oncology Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910549"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09480-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2409932"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62422-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03415-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03414-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02772"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.103115"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.SABCS23-LBO1-02"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3118-z"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30074-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00742-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.028"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07481-w"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-15826-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004356"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07332-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2017.08.027"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.1258"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.229781"},{"key":"e_1_2_7_23_1","first-page":"720","article-title":"CD8\u2010Targeted PET Imaging of Tumor\u2010Infiltrating T Cells in Patients With Cancer: A Phase I First\u2010In\u2010Humans Study of (89)Zr\u2010Df\u2010IAB22M2C, a Radiolabeled Anti\u2010CD8 Minibody","volume":"63","author":"Farwell M. 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