{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:31:47Z","timestamp":1761985907352,"version":"build-2065373602"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Sarcopenia adversely affects clinical outcomes in patients with cancer. Studies indicate that sarcopenia significantly predicts chemotherapy\u2010induced dose\u2010limiting toxicities, including early discontinuation, delay, and dose\u2010reduction, in patients with colorectal, esophageal, digestive, hepatocellular, and renal cancers. The Strength, Assistance for walking, Rising from a chair, Climbing stairs, and Falls (SARC\u2010F) questionnaire is a simple and effective tool for sarcopenia screening. Adjuvant chemotherapy is the standard treatment for advanced (Stages II\/III) colorectal cancer (CRC). Predicting chemotherapy discontinuation could help improve oncologic outcomes. This study aimed to evaluate the correlation between the SARC\u2010F score and chemotherapy discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 139 patients with CRC who underwent surgery between July 2016 and June 2023, received adjuvant chemotherapy and completed the SARC\u2010F questionnaire before surgery. The SARC\u2010F includes five items, each scored from 0 to 2. Patients were divided into two groups based on optimal SARC\u2010F cutoff value. Treatment discontinuation was analyzed using a logistic regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients were categorized into high\u2010SARC\u2010F (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918) and low\u2010SARC\u2010F (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009121) groups. Patients in the high\u2010SARC\u2010F group were older (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), had higher rates of hypertension (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and diabetes mellitus (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), elevated preoperative C\u2010reactive protein levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and a higher incidence of treatment discontinuation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). Univariate and multivariate analyses identified a high SARC\u2010F score as an independent risk factor for chemotherapy discontinuation (odds ratio 3.905, 95% confidence interval 1.100\u201313.867).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that the SARC\u2010F score reflects sarcopenia characteristics and can predict adjuvant chemotherapy discontinuation in patients with CRC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70097","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T12:45:12Z","timestamp":1758372312000},"page":"1235-1242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Strength, Assistance in Walking, Rising From a Chair, Climbing Stairs, and Falls (SARC\u2010F) Score Predicts Adjuvant Chemotherapy Discontinuation in Patients With Colorectal Cancer"],"prefix":"10.1002","volume":"132","author":[{"given":"Dain","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Medicine Keimyung University School of Medicine Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nak Hoon","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Statistics Keimyung University Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woon Kyung","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine Keimyung University and Dongsan Medical Center Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Kyu","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine Keimyung University and Dongsan Medical Center Daegu 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