{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:53:27Z","timestamp":1792086807183,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>This study aims to evaluate the predictive factors associated with failed sentinel lymph node (SLN) mapping in a large, retrospective cohort of patients with early\u2010stage endometrial cancer (EC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively evaluated a series of EC patients who underwent laparoscopic SLN mapping with intracervical indocyanine green (ICG) injection in five referred oncological centers from January 2019 to March 2024. We compared the clinical and pathological features of bilateral and failed SLN mapping, which was defined as either unilateral mapping or no SLN mapping. Logistic regression was used to identify predictors of failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 623 analyzed patients, 437 (70.14%) had a successful bilateral procedure. On univariate analysis, age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), non\u2010endometrioid histology (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and previous vaginal delivery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) were significant associated with failed SLN mapping. On multivariable analysis, only increasing age (OR 1.03; 95% CI, 1.01\u20131.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and non\u2010endometrioid histology (OR 1.81; 95% CI, 1.01\u20133.19) were independently associated with unsuccessful procedure. No significant differences were observed for BMI, enlarged lymph nodes, intraoperative lysis of adhesion, LVSI, grade 3, and FIGO stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increasing age and non\u2010endometrioid histology are independent predictors of bilateral SLN mapping failure in EC patients undergoing SLN mapping with cervical ICG injection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70106","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:34:39Z","timestamp":1760171679000},"page":"1391-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictive Factors for Failed Sentinel Lymph Node Mapping in Endometrial Cancer: A Retrospective Multicenter Study"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0278-1202","authenticated-orcid":false,"given":"Cristina","family":"Taliento","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Obstetrics and Gynecology Unit Ferrara Italy"},{"name":"Department of Development and Regeneration KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Scutiero","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Obstetrics and Gynecology Unit Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cucinella","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit Istituto Nazionale Tumori IRCCS Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Chiantera","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit Istituto Nazionale Tumori IRCCS Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pontrelli","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital of Bolzano (SABES\u2010ASDAA) Teaching Hospital of Paracelsius Medical University (PMU) Bolzano\u2010Bozen Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Klaric","sequence":"additional","affiliation":[{"name":"Clinical Hospital Center Rijeka Clinic for Gynecology and Obstetrics Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Belci","sequence":"additional","affiliation":[{"name":"Department of Gynaecology General Hospital Pula Pula Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Steinkasserer","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital of Bolzano (SABES\u2010ASDAA) Teaching Hospital of Paracelsius Medical University (PMU) Bolzano\u2010Bozen Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Restaino","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Obstetrics and Gynecology Clinic Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby","family":"Martinello","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Obstetrics and Gynecology Unit Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsola","family":"Brasile","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Obstetrics and Gynecology Unit Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Arcieri","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Obstetrics and 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