{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:26:44Z","timestamp":1791041204228,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n We assessed predictors of overall (OS) and cancer\u2010specific survival (CSS) in stage I colorectal cancer (CRC).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Retrospective analysis of patients with stage I colon or rectal adenocarcinomas from the SEER database (2010\u20132020) Survival was assessed using Kaplan\u2010Meier statistics and multivariable Cox regression analyses. The primary outcomes were 5\u2010year OS and CSS.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 40,001 patients (51.3% male; mean age: 65.1\u2009\u00b1\u200912.6 years) were included. Colon and rectal cancers accounted for 75.8% and 24.2%, respectively. Five\u2010year OS and CSS were 83.1% (95% CI: 82.6\u201383.5%) and 93.2% (95% CI: 92.9\u201393.5%), respectively. Factors independently associated with worse OS were age (HR: 1.07;\n p<\/jats:italic>\n \u2009<\u20090.001), male sex (HR:1.48;\n p<\/jats:italic>\n \u2009<\u20090.001), Black race (HR: 1.25;\n p<\/jats:italic>\n \u2009<\u20090.001), single, divorced, or widowed status (HR: 1.49, 1.46, and 1.43;\n p<\/jats:italic>\n \u2009<\u20090.001), tumor size (HR: 1.001;\n p<\/jats:italic>\n \u2009=\u20090.008), poorly differentiated carcinomas (HR: 1.32;\n p<\/jats:italic>\n \u2009<\u20090.001), undifferentiated carcinomas (HR:1.44;\n p<\/jats:italic>\n \u2009=\u20090.026), perineural invasion (HR: 1.84;\n p<\/jats:italic>\n \u2009<\u20090.001), elevated CEA levels (HR: 1.68;\n p<\/jats:italic>\n \u2009<\u20090.001), and systemic therapy (neoadjuvant: HR: 1.3;\n p<\/jats:italic>\n \u2009=\u20090.032, adjuvant: HR: 2.2;\n p<\/jats:italic>\n \u2009<\u20090.001, both: HR: 1.97;\n p<\/jats:italic>\n \u2009<\u20090.001). Factors independently associated with worse CSS were age (HR: 1.05;\n p<\/jats:italic>\n \u2009<\u20090.001), male sex (HR: 1.32;\n p<\/jats:italic>\n \u2009<\u20090.001), Black race (HR: 1.43;\n p<\/jats:italic>\n \u2009<\u20090.001), marital status (HR: 1.44, 1.28, and 1.68;\n p<\/jats:italic>\n \u2009<\u20090.001), tumor size (HR: 1.003;\n p<\/jats:italic>\n \u2009<\u20090.001), poorly differentiated carcinomas (HR: 1.77;\n p<\/jats:italic>\n \u2009<\u20090.001), perineural invasion (HR: 2.29;\n p<\/jats:italic>\n \u2009<\u20090.001), elevated CEA levels (HR: 2.24;\n p<\/jats:italic>\n \u2009<\u20090.001), and systemic therapy (neoadjuvant: HR: 2.53;\n p<\/jats:italic>\n \u2009=\u20090.032, adjuvant: HR: 4.22;\n p<\/jats:italic>\n \u2009<\u20090.001, both: HR: 3.83;\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Although patients with stage I CRC had excellent survival, single, older, Black, male patients with large, high\u2010grade tumors associated with perineural invasion and elevated CEA levels had a higher mortality risk.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jso.70111","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T16:02:50Z","timestamp":1761062570000},"page":"1320-1330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Seer\u2010Based Analysis of Survival Predictors in Stage I Colorectal Adenocarcinomas"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7854-5244","authenticated-orcid":false,"given":"Sameh Hany","family":"Emile","sequence":"first","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida Weston Florida"},{"name":"Colorectal Surgery Unit, General Surgery Department Mansoura University Hospitals Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Horesh","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida Weston Florida"},{"name":"Department of Surgery and Transplantations, Sheba Medical Center, Ramat Gan, Israel Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Garoufalia","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida Weston Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Oosenbrug","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida Weston Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylise","family":"Boutros","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida Weston Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-5753","authenticated-orcid":false,"given":"Steven D.","family":"Wexner","sequence":"additional","affiliation":[{"name":"Ellen Leifer Shulman and Steven Shulman Digestive Disease Center Cleveland Clinic Florida Weston Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208375"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2018.81072"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0029"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12916-020-01618-6","article-title":"Risk Factors and Risk Prediction Models for Colorectal Cancer Metastasis and Recurrence: An Umbrella Review of Systematic Reviews and Meta\u2010Analyses of Observational Studies","volume":"18","author":"Xu W.","year":"2020","journal-title":"BMC 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