{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:51:16Z","timestamp":1764316276250,"version":"3.46.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The indication for sublobar resection is determined based on radiologic findings, but some cases exhibit radiology\u2010pathology discordance. This study aimed to examine the impact of histologic subtypes on radiology\u2010pathology discordance and their preoperative predictability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed 585 patients with clinical stage IA adenocarcinoma and examined the relationship between radiology\u2010pathology discordance and histologic characteristics, focusing on high\u2010grade components: solid (SOL) or micropapillary (MIP). The predictive ability of radiologic or cytopathologic examinations for those subtypes was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Radiology\u2010pathology discordance was found in 148 (25.2%) patients and was significantly associated with the presence of histologic high\u2010grade components, with 71.9% and 70.4% of patients with upstaged lymph node and pleural invasion statuses having high\u2010grade components. The preoperative prediction of high\u2010grade components varied between subtypes, and radiographically pure\u2010solid appearance and high maximum standardized uptake value were independent predictors of the SOL subtype, but not MIP. Among pre\u2010 or intraoperative cytopathologic examinations, intraoperative touch imprint cytology exhibited superior detection ability for MIP component.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Histologic high\u2010grade components are highly associated with radiology\u2010pathology discordance in early\u2010stage lung adenocarcinoma. Radiologic assessment would be beneficial for predicting the SOL subtype, but not MIP. Alternatively, intraoperative cytologic assessment would complement the detection of MIP subtype.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70117","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:20:18Z","timestamp":1761664818000},"page":"1407-1415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance and Preoperative Prediction of High\u2010Grade Subtypes in Early\u2010Stage Lung Adenocarcinoma Eligible for Sublobar Resection"],"prefix":"10.1002","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-421X","authenticated-orcid":false,"given":"Masashi","family":"Mikubo","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Tamagawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuto","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-5791","authenticated-orcid":false,"given":"Dai","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazu","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Ichinoe","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2150-932X","authenticated-orcid":false,"given":"Yukitoshi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kitasato University School of Medicine Sagamihara Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.jtho.2020.06.001","article-title":"A Grading System for Invasive Pulmonary Adenocarcinoma: A Proposal From the International Association for the Study of Lung Cancer Pathology Committee","volume":"15","author":"Moreira A. L.","year":"2020","journal-title":"Journal of Thoracic Oncology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00408-022-00561-y","article-title":"Impact of High\u2010Grade Patterns in Early\u2010Stage Lung Adenocarcinoma: A Multicentric Analysis","volume":"200","author":"Bertoglio P.","year":"2022","journal-title":"Lung"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.athoracsur.2018.07.035","article-title":"Relevance of Intraoperative Pleural Lavage Cytology and Histologic Subtype in Lung Adenocarcinoma","volume":"106","author":"Mikubo M.","year":"2018","journal-title":"Annals of Thoracic Surgery"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jtcvs.2020.09.146","article-title":"A Single\u2010Arm Study of Sublobar Resection for Ground\u2010Glass Opacity Dominant Peripheral Lung Cancer","volume":"163","author":"Suzuki K.","year":"2022","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jtcvs.2023.01.019","article-title":"Long\u2010Term Outcome of Patients With Peripheral Ground\u2010Glass Opacity\u2010Dominant Lung Cancer After Sublobar Resections","volume":"166","author":"Yoshino I.","year":"2023","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S2213-2600(23)00041-3","article-title":"Segmentectomy for Ground\u2010Glass\u2010Dominant Lung Cancer With a Tumour Diameter of 3 cm or Less Including Ground\u2010Glass Opacity (JCOG1211): A Multicentre, Single\u2010Arm, Confirmatory, Phase 3 Trial","volume":"11","author":"Aokage K.","year":"2023","journal-title":"Lancet Respiratory Medicine"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(21)02333-3","article-title":"Segmentectomy Versus Lobectomy in Small\u2010Sized Peripheral Non\u2010Small\u2010Cell Lung Cancer (JCOG0802\/WJOG4607l): A Multicentre, Open\u2010Label, Phase 3, Randomised, Controlled, Non\u2010Inferiority Trial","volume":"399","author":"Saji H.","year":"2022","journal-title":"Lancet"},{"key":"e_1_2_9_9_1","unstructured":"The Japan Lung Cancer Society \u201cJapan Lung Cancer Society Guidelines for Diagnosis and Treatment of the Lung Cancer \u201d2024 https:\/\/www.haigan.gr.jp\/publication\/guideline\/examination\/2024\/."},{"volume-title":"Thoracic Tumours: WHO Classification of Tumours","year":"2021","author":"Board W. 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Y.","year":"2017","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.athoracsur.2019.03.043","article-title":"Utility of Core Biopsy Specimen to Identify Histologic Subtype and Predict Outcome for Lung Adenocarcinoma","volume":"108","author":"Kim T. H.","year":"2019","journal-title":"Annals of Thoracic Surgery"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.21037\/tlcr-21-44","article-title":"A Machine Learning\u2010Based Prediction of the Micropapillary\/Solid Growth Pattern in Invasive Lung Adenocarcinoma With Radiomics","volume":"10","author":"He B.","year":"2021","journal-title":"Translational Lung Cancer Research"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/s41416-023-02241-x","article-title":"Development of the Semi\u2010Dry Dot\u2010Blot Method for Intraoperative Detecting Micropapillary Component in Lung Adenocarcinoma Based on Proteomics Analysis","volume":"128","author":"Xu L.","year":"2023","journal-title":"British Journal of Cancer"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:47:33Z","timestamp":1764316053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.70117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jso.70117"],"URL":"https:\/\/doi.org\/10.1002\/jso.70117","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"type":"print","value":"0022-4790"},{"type":"electronic","value":"1096-9098"}],"subject":[],"published":{"date-parts":[[2025,10,28]]},"assertion":[{"value":"2025-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}