{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:30:19Z","timestamp":1792701019097,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Osteosarcoma (OS) survival rates have remained unchanged for decades, while video\u2010assisted thoracic surgery (VATS) for lung metastasis (LM) became common. We aimed to clarify clinical outcomes of post\u2010relapse survival (PRS) for patients with OS based on LM\u2010free survival (LMFS) across different eras.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010centre retrospective study included 168 patients with OS without LM at initial diagnosis. Patients were categorised into three groups: non\u2010LM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200989), synchronous LM (sLM: less than 1\u2010year LMFS) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940), and mLM (at least 1\u2010year LMFS) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939). We compared PRS in patients with sLM and mLM across periods 1 (1990\u20132005) and 2 (2006\u20132022).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PRS for mLM was longer in period 2 than in period 1 (Hazard ratio: 0.37, 95% confidence interval: 0.12\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), whereas no difference was observed for sLM. In mLM, ratios of surgery, radiotherapy, and chemotherapy were unchanged; the rate of VATS increased in period 2 (7\/18 vs. 10\/12,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). The rate of reoperation remained unchanged (7\/18 vs. 7\/12,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.39).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In period 2, mLM had a better prognosis than in period 1. There was an increased use of VATS, while the rates of reoperation for LM remained unchanged. Conversely, the prognosis for sLM was not altered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70152","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T15:08:46Z","timestamp":1766675326000},"page":"210-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Outcomes and Surgical Procedures for Patients With Osteosarcoma and Metachronous Lung Metastasis: A Chronological Analysis"],"prefix":"10.1002","volume":"133","author":[{"given":"Kazuha","family":"Nakabachi","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Oncology NHO Hokkaido Cancer Center Hokkaido Sapporo Japan"},{"name":"Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine Hokkaido University Hokkaido Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-5900","authenticated-orcid":false,"given":"Hirokazu","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology NHO Hokkaido Cancer Center Hokkaido Sapporo Japan"},{"name":"Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine Hokkaido University Hokkaido Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-0550","authenticated-orcid":false,"given":"Masatake","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine Hokkaido University Hokkaido Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology NHO Hokkaido Cancer Center Hokkaido Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery NHO, Hokkaido Cancer Center Hokkaido Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2099-1687","authenticated-orcid":false,"given":"Yasushi","family":"Mizukami","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery NHO, Hokkaido Cancer Center Hokkaido Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine Hokkaido University Hokkaido Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology NHO Hokkaido Cancer Center Hokkaido Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Hiraga","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology NHO Hokkaido Cancer Center Hokkaido Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34163"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24121"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.16"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-24-01281"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30214-5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000541477.24116.8d"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6674471"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27444"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.001"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.4381"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70475-3"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.10.137"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2009.05.002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22293"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.141"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16173086"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03579-8"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2023.107255"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1683372"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03579-8"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.2305"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.27219"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.063"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.9.1849"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu526"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000001491"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-009-9270-y"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210088"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2020.100281"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-020-10056-w"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14132"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.112822"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.05.052"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.71"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00246-z"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers5020591"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.70152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:36:15Z","timestamp":1770042975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.70152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,25]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jso.70152"],"URL":"https:\/\/doi.org\/10.1002\/jso.70152","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,25]]},"assertion":[{"value":"2025-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}