{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:11:02Z","timestamp":1780924262478,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal cancer screening mainly targets a population between 50 and 70 years of age; however, it is inconsistently implemented in people over 70. The aim of this study was to analyze the association between colorectal cancer (CRC) screening, postoperative mortality, and perioperative and oncologic outcomes in a large population of patients over 70 years of age who underwent surgery for CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data regarding people over 70 who underwent CRC surgery were retrieved from a nationally validated retrospective database, including four consecutive years (2018\u20132021) and 81 centers. The patients were divided into two groups according to their participation in the CRC screening program: Screening versus No Screening. The outcomes of the study were 30\u2010day mortality; urgent, palliative and minimally invasive surgery rates; Clavien\u2010Dindo \u2265 III; advanced oncologic stage; R0 resection and length of hospital stay (LOS). Logistic regression analysis was carried out and adjusted for multiple confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 10,346 patients over 70,676 were in the screening group, and 9670 were in the no screening group. At logistic regression, CRC screening was significantly associated with a reduction in 30\u2010day mortality (OR 0.41, 95% CI 0.18\u20130.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032), urgent surgery (OR 0.06, 95% CI 0.02\u20130.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), palliative surgery (OR 0.32, 95% CI 0.19\u20130.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), Clavien\u2010Dindo \u2265\u2009III complications (OR 0.69, 95% CI 0.51\u20130.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) and advanced oncologic stage (OR 0.53, 95% CI 0.45\u20130.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and a significant increase in R0 resections (OR 3.15, 95% CI 1.67\u20135.94,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and laparoscopic surgery (OR 1.93, 95% CI 1.57\u20132.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The crude and adjusted Odds Ratio similarity confirmed this correlation, regardless of the comorbidities and confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adherence to CRC screening should be further encouraged and standardized for people over 70.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70206","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T17:31:54Z","timestamp":1771781514000},"page":"572-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Colorectal Cancer Screening and Survival in Patients Older Than 70 Years: Results of A National Multicenter Retrospective Study"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0278-4139","authenticated-orcid":false,"given":"Matteo","family":"Rottoli","sequence":"first","affiliation":[{"name":"Surgery of the Alimentary Tract IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7460-9578","authenticated-orcid":false,"given":"Giacomo","family":"Calini","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-7774","authenticated-orcid":false,"given":"Giovanni","family":"Castagna","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-0618","authenticated-orcid":false,"given":"Alice","family":"Gori","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-5176","authenticated-orcid":false,"given":"Stefano","family":"Cardelli","sequence":"additional","affiliation":[{"name":"Surgery of the Alimentary Tract IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1493-1768","authenticated-orcid":false,"given":"Antonino","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Italy"},{"name":"IRCCS Humanitas Research Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-6421","authenticated-orcid":false,"given":"Gianluca","family":"Pellino","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences Universit\u00e0 degli Studi della Campania Luigi Vanvitelli Naples Italy"},{"name":"Colorectal Surgery University Hospital Vall d'Hebron Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Bianconi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Fiore","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Rosati","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery Division IRCCS San Raffaele Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Morino","sequence":"additional","affiliation":[{"name":"AOU Citt\u00e0 della Salute e della Scienza Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"de Manzini","sequence":"additional","affiliation":[{"name":"General Surgery Department University Hospital of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pietrabissa","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pavia and Fondazione IRCCS Policlinico San Matteo Pavia 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