{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:08Z","timestamp":1786978148546,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["APC"],"award-info":[{"award-number":["APC"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pathological complete response (pCR) after neoadjuvant chemotherapy is associated with improved prognosis in patients with triple\u2010negative breast cancer (TNBC). Differences in pathological response rates between the breast and axillary lymph nodes have prompted interest in understanding response patterns that may, in the future, inform strategies aimed at omitting axillary surgical evaluation. This systematic review aimed to describe and compare the prevalence of breast and axillary pathological responses in TNBC patients treated with neoadjuvant chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review was conducted following the PRISMA statement and registered in PROSPERO (ID: CRD498121). Searches were performed in the PubMed, Embase, and Web of Science databases. Studies that described node pathological response (NpCR) and breast pathological response (BpCR) in TNBC patients undergoing neoadjuvant chemotherapy were included. Article selection was independently performed by two reviewers using the Rayyan platform. The methodological quality of the included studies was assessed using the Newcastle\u2010Ottawa Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across the included studies, NpCR rates were consistently higher than BpCR rates in TNBC patients. No study reported higher BpCR compared with NpCR. The mean prevalence of BpCR was 32% (SD 0.6), NpCR was 38.3% (SD 0.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among TNBC patients treated with neoadjuvant chemotherapy, NpCR occurs more frequently than BpCR. These findings provide a descriptive overview of current response patterns and may inform future research exploring the safety of omitting axillary surgical evaluation. Factors beyond tumor subtype likely influence response patterns, indicating the need for further research to identify predictive biomarkers and optimize treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70213","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T18:51:33Z","timestamp":1771181493000},"page":"712-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: A Systematic Review of Breast and Node Pathologic Response"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-1873","authenticated-orcid":false,"given":"Milena Martello","family":"Crist\u00f3falo","sequence":"first","affiliation":[{"name":"Institute of Cancer of the State of S\u00e3o Paulo, School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1725-8732","authenticated-orcid":false,"given":"Jonathan Yugo","family":"Maesaka","sequence":"additional","affiliation":[{"name":"Institute of Cancer of the State of S\u00e3o Paulo, School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-5137","authenticated-orcid":false,"given":"Deise Azevedo","family":"Pereira","sequence":"additional","affiliation":[{"name":"Memorial Arthur Ramos Hospital\u2014rede D'Or, R. Hugo Corr\u00eaa Paes Macei\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3987-5237","authenticated-orcid":false,"given":"Gabriela Bezerra","family":"N\u00f3brega","sequence":"additional","affiliation":[{"name":"Institute of Cancer of the State of S\u00e3o Paulo, School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-6972","authenticated-orcid":false,"given":"Yedda Nunes","family":"Reis","sequence":"additional","affiliation":[{"name":"Institute of Cancer of the State of S\u00e3o Paulo, School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3757-9901","authenticated-orcid":false,"given":"Jos\u00e9 Maria Soares","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Institute of Cancer of the State of S\u00e3o Paulo, School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0111-9030","authenticated-orcid":false,"given":"Edmund Chada","family":"Baracat","sequence":"additional","affiliation":[{"name":"Institute of Cancer of the State of S\u00e3o Paulo, School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Roberto","family":"Filassi","sequence":"additional","affiliation":[{"name":"Institute of Cancer of the State of S\u00e3o Paulo, School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.8595"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62422-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.5.1304"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0891"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70166-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278932"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.7827"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2021.0033"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161-1041.S2-001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910549"},{"key":"e_1_2_9_12_1","first-page":"16","article-title":"Omission of Breast Surgery for Predicted Pcr Patients with Mri and Vacuum\u2010Assisted Biopsy in Breast Cancer After Neoadjuvant Chemotherapy: A Multicenter, Single\u2010Arm, Non\u2010Inferiority Trial (Optimist Trial)","volume":"41","author":"Ji\u2010Jung J.","year":"2023","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2024.108277"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.e12090"},{"key":"e_1_2_9_15_1","unstructured":"University Ok York. National Institute for Health and Care Research. [Online] 2024. [Citado em: 11 de 12 de 2024]https:\/\/www.crd.york.ac.uk\/prospero\/."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","unstructured":"Rayyan\u2014A web and mobile app for systematic reviews. Ouzzani Mourad et al. 210 2016 Systematic Reviews Vol. 5.https:\/\/doi.org\/10.1186\/s13643-016-0384-4.","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_9_18_1","unstructured":"G.Wells B. J.Shea D.O'Connell et al. The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses [Internet](Ottawa Hospital Research Institute 2026) https:\/\/ohri.ca\/en\/who-we-are\/core-facilities-and-platforms\/ottawa-methods-centre\/newcastle-ottawa-scale."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.0562"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489785"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13206"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2019.22.e35"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000924"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002953"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-10195-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512202"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.20.1294"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2023.03.009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512202"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032969"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0397"},{"key":"e_1_2_9_32_1","unstructured":"V. G.Kaklamani C.Graham K. L.Tedesco et al. \u201cUsing BluePrint to Elucidate the Molecular Heterogeneity of Triple-Negative Breast Cancers [poster] \u201d in San Antonio Breast Cancer Symposium 2020; 8\u201311 Dec (2020).https:\/\/agendia.com\/wp-content\/uploads\/2020\/12\/SABCS-2020-TNBC-BluePrint-Poster-FINAL.pdf."},{"key":"e_1_2_9_33_1","unstructured":"M. J.PeetersandF. H.Duijnhoven. Avoiding Sentinel Lymph Node Biopsy in Breast Cancer Patients After Neoadjuvant Chemotherapy (ASICS). s.l.: ClinicalTrials.gov 2020. NCT04225858."},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000558"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2019.05.019"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13050865"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.70213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:05:33Z","timestamp":1777521933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.70213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/jso.70213"],"URL":"https:\/\/doi.org\/10.1002\/jso.70213","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,15]]},"assertion":[{"value":"2025-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}