{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:23:38Z","timestamp":1777861418826,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Although multiple studies have reported the anti\u2010tumor effects of aspirin on colorectal cancer, its benefit in patients with colorectal cancer following curative resection remains controversial. This study aimed to evaluate the effect of aspirin administration in patients with stage I\u2013III colorectal cancer following curative resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multi\u2010institutional retrospective study included 2,863 patients with stage I\u2013III colorectal cancer who underwent curative resection between January 2017 and December 2019. Patients were classified into two groups according to aspirin use. Clinical characteristics and oncological outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The aspirin group was older, and fewer patients had advanced pathological tumor stages or received postoperative adjuvant chemotherapy than non\u2010aspirin group. Aspirin use tended to be associated with improved postoperative prognosis in patients with stage I\u2013III colorectal cancer (overall survival: 91.1% vs. 80.9%, hazard ratio\u2009=\u20090.646, 95% confidence interval\u2009=\u20090.32\u20131.30; recurrence\u2010free survival: 82.6% vs. 73.7%, hazard ratio\u2009=\u20090.730, 95% confidence interval\u2009=\u20090.44\u20131.20). After propensity score matching to minimize bias between groups, aspirin use was associated with improved postoperative prognosis (overall survival: 91.0% vs. 69.8%, hazard ratio\u2009=\u20090.306, 95% confidence interval\u2009=\u20090.14\u20130.68; recurrence\u2010free survival: 82.4% vs. 56.6%, hazard ratio\u2009=\u20090.350, 95% confidence interval\u2009=\u20090.19\u20130.62). Aspirin use significantly improved recurrence\u2010free survival in patients with advanced cancer who were recommended to receive postoperative adjuvant chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study suggests that aspirin use is associated with improved postoperative prognosis in patients with stage I\u2013III colorectal cancer after curative resection. Aspirin may be beneficial for advanced\u2010stage patients, for whom postoperative adjuvant chemotherapy is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70217","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:31:36Z","timestamp":1773905496000},"page":"720-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Aspirin on Recurrence Prevention After Curative Resection for Stage I\u2013III Colorectal Cancer: A Multi\u2010Institutional Retrospective Study"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0155-2360","authenticated-orcid":false,"given":"Tomoaki","family":"Bekki","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima 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