{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:04:12Z","timestamp":1784145852327,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the ability of perioperative inflammatory markers to discriminate postoperative complications within 6 months in patients with ovarian cancer\u2013related peritoneal metastasis undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included patients with ovarian cancer\u2013related peritoneal metastasis who underwent CRS and HIPEC between January 2011 and August 2022. Data were obtained from the Hospital Information Management System, patient medical records, and anesthesia charts. Systemic immune\u2010inflammation index (SII), neutrophil\u2013lymphocyte ratio (NLR), and platelet\u2013lymphocyte ratio (PLR) were assessed preoperatively (within 7 days before surgery) and on postoperative days 1, 3, and 5. Postoperative complications occurring within 6 months were graded according to the Clavien\u2013Dindo classification; major complications were defined as Clavien\u2013Dindo grade \u2265III. Receiver operating characteristic (ROC) curve analysis was used to evaluate the discriminatory performance of inflammatory markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the preoperative period, AUCs were 0.655 (95% CI: 0.568\u20130.742) for NLR, 0.655 (95% CI: 0.568\u20130.742) for PLR, and 0.689 (95% CI: 0.607\u20130.772) for SII. On POD3, AUCs were 0.638 (0.551\u20130.726), 0.619 (0.531\u20130.707), and 0.673 (0.589\u20130.758), respectively. On POD5, AUCs were 0.724 (0.645\u20130.803), 0.695 (0.612\u20130.779), and 0.740 (0.663\u20130.818), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Perioperative NLR, PLR, and SII showed measurable discrimination for 6\u2010month postoperative complications, with numerically higher AUCs on POD5.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70243","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T06:26:02Z","timestamp":1775111162000},"page":"918-925","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory Markers may Determine Postoperative Complications in Cases of Peritoneal Carcinomatosis of Ovarian Origin Treated With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy"],"prefix":"10.1002","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2036-019X","authenticated-orcid":false,"given":"Donmez","family":"Mustafa","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Ba\u015fak\u015fehir Cam and Sakura City Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisgin","family":"Tayfun","sequence":"additional","affiliation":[{"name":"Department of General Surgery Dokuz Eylul University Medical Faculty Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoglu","family":"Berke","sequence":"additional","affiliation":[{"name":"Department of General Surgery Dokuz Eylul University Medical Faculty Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokmen","family":"Selman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sensoy Basoglu","family":"Ecem","sequence":"additional","affiliation":[{"name":"Department of Public Health Prov\u0131nc\u0131al Health D\u0131rectorate Corum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-754X","authenticated-orcid":false,"given":"Boztas","family":"Nilay","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Dokuz Eylul University Medical Faculty Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgul Ozkardesler","family":"Sevda","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Dokuz Eylul University Medical Faculty Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199501000-00004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1247-5_23"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1430-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.9640"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3213-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708618"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2016.06.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.09.030"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.09.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.04.013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08619-y"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-22-716"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02482-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4096-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2022.01.104"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.70243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T19:33:49Z","timestamp":1784144029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.70243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jso.70243"],"URL":"https:\/\/doi.org\/10.1002\/jso.70243","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2025-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}