{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:23:17Z","timestamp":1787318597360,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010CA008748"],"award-info":[{"award-number":["P30\u2010CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reference values provide clinically meaningful context for interpreting patient\u2010reported outcome measures. However, these values may evolve over time with changes in reconstructive practice and may differ across cultural settings. This study compares BREAST\u2010Q scores across time periods and countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients who underwent postmastectomy breast reconstruction and completed the BREAST\u2010Q at Memorial Sloan Kettering Cancer Center (MSKCC) and Maastricht University Medical Center (MUMC\u2009+) between 2007 and 2022 were included. BREAST\u2010Q scores from an original MSKCC cohort (2007\u20102017) were compared with a recent MSKCC cohort (2018\u20102022) to evaluate temporal differences, and with a Dutch cohort (2013\u20102022) to assess geographic variation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 7,199 MSKCC patients (3,243 original; 3,956 recent), and 444 MUMC+ patients were included. Compared with the original MSKCC cohort, the recent cohort demonstrated improved Physical Well\u2010being of the Chest among implant\u2010based reconstruction patients at preoperative (81 [74, 91]\n                      <jats:italic>vs.<\/jats:italic>\n                      85 [74, 100]) and at 2\u2010years postoperative (76 [66, 85]\n                      <jats:italic>vs.<\/jats:italic>\n                      80 [64, 92]). Other BREAST\u2010Q domains, on the other hand, declined in both implant\u2010based and autologous reconstruction groups. Compared with MSKCC patients, the Dutch cohort reported lower Physical Well\u2010being of the Chest, but higher Sexual Well\u2010being. For example, at 2\u2010years postoperative, MUMC+ patients scored 10 points higher on Sexual Well\u2010being than MSKCC patients (60 [47, 72]\n                      <jats:italic>vs.<\/jats:italic>\n                      50 [36, 66],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BREAST\u2010Q reference values vary over time and across cultural contexts. Contemporary population\u2010specific reference values may improve interpretation of patient\u2010reported outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70271","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:50:04Z","timestamp":1778482204000},"page":"31-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Time and Place on BREAST\u2010Q REACT: A Multi\u2010Institutional Examination"],"prefix":"10.1002","volume":"134","author":[{"given":"Minji","family":"Kim","sequence":"first","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeske M.","family":"Bubberman","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York USA"},{"name":"Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7490-8994","authenticated-orcid":false,"given":"Jennifer","family":"Wang","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery Service, Department of Surgery Memorial Sloan Kettering Cancer Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian A.","family":"Boe","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 R.W.J.","family":"Van der Hulst","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Center Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-3962","authenticated-orcid":false,"given":"Stefania M. 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