{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:11:48Z","timestamp":1784304708502,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>NCCN guidelines recommend right hemicolectomy (RHC) for appendiceal neuroendocrine tumors (aNETs)\u2009&gt;\u20092\u2009cm and observation for &lt;\u20091\u2009cm. However, optimal surgical management of 1\u20132\u2009cm tumors remains controversial. This study compared long\u2010term survival and recurrence between patients undergoing RHC versus appendectomy (APY) for 1\u20132\u2009cm aNETs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with pathologically confirmed 1\u20132\u2009cm aNETs treated at three Mayo Clinic sites (1972\u20132024) were included. Primary outcomes were recurrence and all\u2010cause mortality after resection. Associations with lymph node (LN) metastasis were assessed in patients with lymphadenectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty\u2010five patients were identified: 29 (45%) underwent APY, 35 (54%) RHC, and one ileocecectomy. Median age at diagnosis was 39 years; 71% were female and 94% white. LN positivity was 15.2% for tumors with nodes examined. Tumor size &gt;\u20091.5\u2009cm, stage T3\/T4, and lymphovascular invasion were not associated with nodal metastasis. No survival differences were observed between APY and RHC. LN positivity did not impact survival. No recurrences occurred during a median follow\u2010up of 6.25 years (IQR 2.44\u201312.63).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients with 1\u20132\u2009cm aNETs, RHC conferred no survival benefit over APY. Absence of recurrence and the limited prognostic value of nodal disease suggest APY alone may suffice for this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70274","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:44:34Z","timestamp":1777524274000},"page":"91-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["De\u2010Escalating Surgery for 1\u20132 cm Appendiceal Neuroendocrine Tumors: A North American Multi\u2010Center Analysis"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-2243","authenticated-orcid":false,"given":"Richard Max","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Surgery Mayo Clinic, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po Hong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Saleeb","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Ven","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Chee","family":"Stucky","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay P.","family":"Bagaria","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic, Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel M.","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic, Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7753-097X","authenticated-orcid":false,"given":"Travis E.","family":"Grotz","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic, Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Wasif","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic, Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.233025134"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0081"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i13.1304"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13332"},{"key":"e_1_2_10_6_1","unstructured":"NANETS Guidelines Compendium: Consensus Guidelines for Surveillance and Management of Neuroendocrine Tumors. 5. North American Neuroendocrine Tumor Society Accessed October 12 2025 https:\/\/nanets.net\/net-guidelines-library."},{"key":"e_1_2_10_7_1","article-title":"Pathology Outlines \u2010 Neuroendocrine Tumor","author":"Ding Chien\u2010Kuang Cornelia Ding","year":"2025","journal-title":"PathologyOutlines.com"},{"key":"e_1_2_10_8_1","unstructured":"A. B.Benson S.Hoffe andS.Nurkin.Neuroendocrine and Adrenal Tumors NCCN Guidelines Version 1.2026 p MS\u20109. accessed January 2026."},{"issue":"41","key":"e_1_2_10_9_1","first-page":"1","article-title":"Current Management of Appendiceal Neoplasms","volume":"41","author":"Hoehn R. 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