{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:09:54Z","timestamp":1784304594885,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Post\u2010hepatectomy liver failure (PHLF) following major hepatectomy (MH) increases the risk of morbidity and death. The relationship between institutional MH volume, PHLF, and outcomes is not well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults undergoing MH from 2014 to 2021 in the ACS NSQIP hepatectomy\u2010targeted database were included. Rates of PHLF were compared based on hospital\u2010level annual MH volume. Multivariable logistic regression evaluated the association between volume, PHLF grade, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across 11,167 patients, PHLF incidence was 3.7% in low\u2010volume, 5.5% in low\u2010medium volume, 6.9% in medium\u2010high volume, 11.8% in high\u2010volume centers (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The adjusted odds ratio (aOR) for morbidity in grade B\/C PHLF compared to those without PHLF was elevated in both lower\u2010volume centers (quartiles 1\u20133), (11.2 [7.04\u201317.70]) and in high\u2010volume centers, (8.47 [6.06\u201311.85]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher annual major hepatectomy volume is associated with increased PHLF, which may be a function of complex disease treated at these institutions. PHLF precedes other adverse events affecting both high and low volume institutions. PHLF is an important target for quality improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70280","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T10:13:20Z","timestamp":1778062400000},"page":"76-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hospital Volume and Post\u2010Hepatectomy Liver Failure After Major Hepatectomy"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9079-1614","authenticated-orcid":false,"given":"Xane D.","family":"Peters","sequence":"first","affiliation":[{"name":"Department of Surgery, Northwestern Quality Improvement Research and Education in Surgery Chicago Illinois USA"},{"name":"American College of Surgeons Division of Research and Optimal Patient Care Chicago Illinois USA"},{"name":"Department of Surgery Loyola University Medical Center Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Brajcich","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northwestern Quality Improvement Research and Education in Surgery Chicago Illinois USA"},{"name":"Department of Surgery Chicago Northwestern University  Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bona","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northwestern Quality Improvement Research and Education in Surgery Chicago Illinois USA"},{"name":"Department of Surgery Stanford University Medicine Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-6058","authenticated-orcid":false,"given":"Catherine","family":"Valukas","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northwestern Quality Improvement Research and Education in Surgery Chicago Illinois USA"},{"name":"Department of Surgery Chicago Northwestern University  Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Janczewski","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northwestern Quality Improvement Research and Education in Surgery Chicago Illinois USA"},{"name":"Department of Surgery Chicago Northwestern University  Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford Y.","family":"Ko","sequence":"additional","affiliation":[{"name":"American College of Surgeons Division of Research and Optimal Patient Care Chicago Illinois USA"},{"name":"Department of Surgery University of California Los Angeles David Geffen School of Medicine, VA Greater Los Angeles Healthcare System Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Merkow","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0745-3341","authenticated-orcid":false,"given":"Henry A.","family":"Pitt","sequence":"additional","affiliation":[{"name":"Rutgers Cancer Institute of New Jersey New Brunswick New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Bentrem","sequence":"additional","affiliation":[{"name":"Department of Surgery, Northwestern Quality Improvement Research and Education in Surgery Chicago Illinois USA"},{"name":"Department of Surgery Chicago Northwestern University  Illinois USA"},{"name":"Jesse Brown Veterans Affairs Medical Center Chicago Illinois 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