{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:46:23Z","timestamp":1791863183270,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0734"],"award-info":[{"award-number":["2024NSFSC0734"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Laparoscopic pancreatoduodenectomy (LPD) offers the potentially clinical benefit for patients presenting with periampullary tumors. The aim of this study is to evaluate postoperative clinical outcomes among patients undergoing LPD for periampullary cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We retrospectively reviewed and analyzed 574 consecutive patients received LPD for periampullary cancer at our institution between April 2011 and August 2024. Data collected included preoperative, perioperative, and postoperative information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 574 patients undergoing LPD for periampullary cancer, 311 (54.2%) pathologically diagnosed with pancreatic ductal adenocarcinoma (PDAC) and 263 (45.8%) had non\u2010PDAC periampullary cancer. Compared with PDAC, non\u2010PDAC patients experienced significantly higher rates of major morbidity (16.7% vs 10.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043), including postoperative pancreatic fistula (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), abdominal infection (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032), and reoperation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021). Multivariate analysis identified age \u2265\u200965 years (OR 1.803, 95%CI: 1.092\u2009~\u20092.978), prolonged operative time (OR 1.004, 95%CI: 1.001\u2009~\u20091.006), and non\u2010PDAC pathology (OR 1.664, 95%CI: 1.014\u2009~\u20092.731) as independent risk factors for severe complications, while pylorus preservation was protective (OR 0.460, 95%CI: 0.264\u2009~\u20090.803).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postoperative morbidity after LPD varies by periampullary cancer subtype, with non\u2010PDAC patients at greater risk of severe complications. Older age, prolonged operative time, and non\u2010PDAC pathology were independent predictors of severe complications, whereas pylorus preservation conferred a protective effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jso.70286","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:01:57Z","timestamp":1778482917000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Severe Complications After Laparoscopic Pancreatoduodenectomy in PDAC vs Non\u2010PDAC Periampullary Cancer: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"134","author":[{"given":"Yunwei","family":"Sun","sequence":"first","affiliation":[{"name":"Division of Pancreatic Surgery, Department of General Surgery and Laboratory of Pancreatic Cancer, West China Hospital Sichuan University Chengdu Sichuan China"},{"name":"West China School of Medicine Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pancreatic Surgery, Department of General Surgery and Laboratory of Pancreatic Cancer, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chengdu Shangjin Nanfu Hospital Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugui","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Pancreatic Surgery, Department of General Surgery and Laboratory of Pancreatic Cancer, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianrui","family":"Kuang","sequence":"additional","affiliation":[{"name":"Division of Pancreatic Surgery, Department of General Surgery and Laboratory of Pancreatic Cancer, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2307-1301","authenticated-orcid":false,"given":"Bing","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Pancreatic Surgery, Department of General Surgery and Laboratory of Pancreatic Cancer, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4976-7306","authenticated-orcid":false,"given":"Zhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Pancreatic Surgery, Department of General Surgery and Laboratory of Pancreatic Cancer, West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00642443"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000002850"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-025-11677-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000002035"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.70074"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-12701-y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25336"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6446-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08533-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b13ca2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.11.014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.02.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.05.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.06.058"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.12.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02128-w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000006037"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2017.1385894"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000004855"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.46113"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2021.04.027"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006053.pub6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-025-11833-y"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-023-10470-7"}],"container-title":["Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jso.70286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jso.70286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:05:26Z","timestamp":1791860726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jso.70286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jso.70286"],"URL":"https:\/\/doi.org\/10.1002\/jso.70286","archive":["Portico"],"relation":{},"ISSN":["0022-4790","1096-9098"],"issn-type":[{"value":"0022-4790","type":"print"},{"value":"1096-9098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"2025-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}