{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:14:01Z","timestamp":1788279241789,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Oncology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although ovarian cancer is the most lethal among gynecological cancers, access to massive BRCA testing is still limited. Its cost\u2010effectiveness is still a topic of discussion in several countries. In Brazil, olaparib was recently incorporated into the public health system, access to BRCA testing is still limited. In this article, we aim to review the cost\u2010effectiveness of offering BRCA testing to the at\u2010risk population. A working group composed of 14 specialists in surgical oncology and cancer genetics was established to discuss the cost\u2010effectiveness of population\u2010based BRCA testing for ovarian cancer. The project was divided into five main areas, each with subtopics assigned among the 14 participants. They were: the existing clinical testing guidelines, the current healthcare infrastructure in the Brazilian public health system, cost\u2010effectiveness analysis, challenges in implementing prophylactic surgeries, and family counseling and risk communication. A comprehensive literature review was conducted, followed by a series of meetings among the article's contributors to reach consensus on unresolved issues. These discussions aimed to build recommendations based on the best available scientific evidence. Using as a basis the current structure already existing within the Brazilian public health service (SUS [Sistema \u00danico de Saude]), and based on the testing of the at\u2010risk population chosen by our experts, we estimated savings. The net savings for a population of 100\u2009000 women would range from BRL 7030.30 (US$1255.41) to BRL 1853.92 (US$331.05). And these costs could have an even greater impact when public service PARP inhibitors are incorporated. The working group of the Brazilian Society of Surgical Oncology understands that large\u2010scale BRCA testing is cost\u2010effective, especially when risk\u2010reducing surgery is implemented. Other measures are important, such as training teams of non\u2010specialists to recognize the population at risk, in addition to creating an entire line of care for patients with ovarian cancer in the SUS.<\/jats:p>","DOI":"10.1002\/jso.70302","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:40:10Z","timestamp":1784623210000},"page":"337-348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brazilian Society of Surgical Oncology Analysis in Cost\u2010Effectiveness of Population\u2010Based BRCA Testing for Ovarian Cancer in the Public Health System"],"prefix":"10.1002","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-6752","authenticated-orcid":false,"given":"Alexandre Ferreira","family":"Oliveira","sequence":"first","affiliation":[{"name":"Hospital Universitario Juiz de Fora Federal University Juiz de Fora Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6712-6875","authenticated-orcid":false,"given":"Antonio Ab\u00edlio Pereira","family":"de Santa Rosa","sequence":"additional","affiliation":[{"name":"Brazilian National Cancer Institute Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1452-6137","authenticated-orcid":false,"given":"Audrey Tieko","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Gynecology Oncology Department Erasto Gartner Hospital and Pontif\u00edcia Universidade Cat\u00f3lica Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1321-9442","authenticated-orcid":false,"given":"Bruno Roberto Braga","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department Hospital S\u00e3o Vicente Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8598-2610","authenticated-orcid":false,"given":"Erika Martins","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Diagnostic Support Unit of the Production and Health Innovation Oswaldo Cruz Foundation Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-5582","authenticated-orcid":false,"given":"Glauco","family":"Baiocchi","sequence":"additional","affiliation":[{"name":"Gynecoloy Oncology Departent AC Camargo Cancer Center S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-829X","authenticated-orcid":false,"given":"Jorge Soares","family":"Lyra","sequence":"additional","affiliation":[{"name":"Aldenora Bello Cancer Hospital S\u00e3o Luis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-2017","authenticated-orcid":false,"given":"Paulo Henrique","family":"de Sousa Fernandes","sequence":"additional","affiliation":[{"name":"Surgical Oncology Federal University of Uberlandia Uberl\u00e2ndia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7791-6645","authenticated-orcid":false,"given":"Renato Morato","family":"Zanatto","sequence":"additional","affiliation":[{"name":"Hospital Amaral Carvalho Ja\u00fa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-3854","authenticated-orcid":false,"given":"Reitan","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Department of Oncology, Division of Gynecology Oncology McGill University Health Centre Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-9016","authenticated-orcid":false,"given":"Ren\u00e9 Aloisio","family":"da Costa Vieira","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology. 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